PMID- 18614153
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20161031
IS  - 0003-4266 (Print)
IS  - 0003-4266 (Linking)
VI  - 69
IP  - 5
DP  - 2008 Nov
TI  - [Chronic use of proton-pump inhibitors associated with giardiasis: A rare cause 
      of hypomagnesemic hypoparathyroidism?].
PG  - 446-8
LID - 10.1016/j.ando.2008.03.003 [doi]
AB  - Hypomagnesemia is a rare cause of hypoparathyroidism that can have a very serious 
      clinical presentation. We report the case of a 62-year-old woman hospitalized for 
      exploration of acute tetraparesis with vomiting and swallowing disorders 
      associated with a severe hypocalcemia. Biological explorations revealed 
      hypoparathyroidism (PTH=16ng/L) related to low plasma and erythrocyte magnesium 
      (0.32 and 1.32mmol/L, respectively) as well as hypocalciuria and hypomagnesuria 
      linked to gastrointestinal malabsorption. Etiologic investigations led to the 
      discovery of Giardiasis lamblia on duodenal biopsies and a long-term treatment 
      with proton pump inhibitors (PPI) (omeprazole followed by esomeprazole), both 
      being recently described as causal factors of hypomagnesemic hypoparathyroidism. 
      After treatment of the parasite (by metronidazole) and discontinuation of the 
      PPI, both calcium and magnesium levels returned to normal. Selective 
      malabsorption has been previously reported in patients with giardiasis. The 
      specific mechanism of PPI participation in the genesis of hypomagnesemia remains 
      a subject of debate.
FAU - Francois, M
AU  - Francois M
AD  - Service d'endocrinologie et maladies metaboliques, CHU Robert-Debre, 3, rue du 
      General-Koenig, 51092 Reims, France. mfrancois@chu-reims.fr
FAU - Levy-Bohbot, N
AU  - Levy-Bohbot N
FAU - Caron, J
AU  - Caron J
FAU - Durlach, V
AU  - Durlach V
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Prise chronique d'inhibiteurs de la pompe a protons associee a une giardiase : 
      une cause rare d'hypoparathyroidisme hypomagnesemique ?
DEP - 20080709
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Deglutition Disorders/etiology
MH  - Duodenum/parasitology
MH  - Esomeprazole
MH  - Female
MH  - Giardiasis/*complications/drug therapy/parasitology
MH  - Humans
MH  - Hypocalcemia/etiology
MH  - Hypoparathyroidism/blood/*etiology
MH  - Magnesium Deficiency/blood/*etiology
MH  - Middle Aged
MH  - Omeprazole/adverse effects/therapeutic use
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Quadriplegia/etiology
MH  - Vomiting/etiology
EDAT- 2008/07/11 09:00
MHDA- 2009/02/25 09:00
CRDT- 2008/07/11 09:00
PHST- 2007/09/03 00:00 [received]
PHST- 2008/02/28 00:00 [revised]
PHST- 2008/03/13 00:00 [accepted]
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
AID - S0003-4266(08)00086-3 [pii]
AID - 10.1016/j.ando.2008.03.003 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2008 Nov;69(5):446-8. doi: 10.1016/j.ando.2008.03.003. 
      Epub 2008 Jul 9.