PMID- 18614811
OWN - NLM
STAT- MEDLINE
DCOM- 20081010
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 49
IP  - 10
DP  - 2008 Oct
TI  - Retinal peripapillary nerve fiber layer thickness in neuromyelitis optica.
PG  - 4412-7
LID - 10.1167/iovs.08-1815 [doi]
AB  - PURPOSE: To measure the thickness of retinal peripapillary nerve fibers 
      throughout the course of neuromyelitis optica (NMO). METHODS: This study was of a 
      cross-sectional design, examining the thickness of the retinal peripapillary 
      nerve fiber layer by optical coherence tomography, in patients with NMO (n = 15; 
      30 eyes), patients with multiple sclerosis (MS; n = 15; 30 eyes), and a control 
      group (n = 23; 46 eyes). The thicknesses were acquired according to protocol with 
      the fast RNFL (Retinal Nerve Fiber Layer) procedure. The study of visual function 
      includes for each eye a determination of refraction, measurement of visual 
      acuity, measurement of contrast vision, an analysis of color vision, and a 
      frequency-doubling technology perimetry (FDTP). The main outcome measurements 
      were the thickness of the retinal peripapillary nerve fibers, visual acuity, and 
      scores of contrast vision. RESULTS: The average thickness of retinal 
      peripapillary nerve fibers was respectively in the NMO, MS, and control group: 
      65.44 +/- 24.19, 83.85 +/- 24.12, and 106.24 +/- 12.46 microm (P = 0.01). The 
      average thickness of retinal peripapillary nerve fibers correlated to visual 
      acuity, the scores of contrast vision, the scores of FDTP, and the number of 
      episodes per patient (r = -0.58, P = 0.03). CONCLUSIONS: This is the first study 
      to produce measurements of the thickness of retinal peripapillary nerve fibers 
      during optic neuropathies of NMO. The optic neuropathies of NMO are also 
      accompanied by an acute and chronic axonal loss, as clearly illustrated by the 
      OCT.
FAU - Merle, Harold
AU  - Merle H
AD  - Services d'Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, 
      Hopital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies. 
      harold.merle@chu-fortdefrance.fr
FAU - Olindo, Stephane
AU  - Olindo S
FAU - Donnio, Angelique
AU  - Donnio A
FAU - Richer, Raymond
AU  - Richer R
FAU - Smadja, Didier
AU  - Smadja D
FAU - Cabre, Philippe
AU  - Cabre P
LA  - eng
PT  - Journal Article
DEP - 20080709
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Color Perception/physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Neuromyelitis Optica/*physiopathology
MH  - Optic Disk
MH  - Refraction, Ocular/physiology
MH  - Retinal Ganglion Cells/*pathology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
EDAT- 2008/07/11 09:00
MHDA- 2008/10/11 09:00
CRDT- 2008/07/11 09:00
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/10/11 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
AID - iovs.08-1815 [pii]
AID - 10.1167/iovs.08-1815 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4412-7. doi: 10.1167/iovs.08-1815. 
      Epub 2008 Jul 9.