PMID- 18615010
OWN - NLM
STAT- MEDLINE
DCOM- 20090617
LR  - 20211028
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 34
IP  - 6
DP  - 2009 May
TI  - Early parental deprivation in the marmoset monkey produces long-term changes in 
      hippocampal expression of genes involved in synaptic plasticity and implicated in 
      mood disorder.
PG  - 1381-94
LID - 10.1038/npp.2008.106 [doi]
AB  - In mood disorder, early stressors including parental separation are vulnerability 
      factors, and hippocampal involvement is prominent. In common marmoset monkeys, 
      daily parental deprivation during infancy produces a prodepressive state of 
      increased basal activity and reactivity in stress systems and mild anhedonia that 
      persists at least to adolescence. Here we examined the expression of eight genes, 
      each implicated in neural plasticity and in the pathophysiology of mood disorder, 
      in the hippocampus of these same adolescent marmosets, relative to their normally 
      reared sibling controls. We also measured hippocampal volume. Early deprivation 
      led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, 
      serotonin 1A receptor (5-HT(1A)R) mRNA and binding ([3H]WAY100635), and to 
      increased vesicular GABA transporter mRNA. Brain-derived neurotrophic factor 
      (BDNF), synaptophysin, vesicular glutamate transporter 1 (VGluT1), 
      microtubule-associated protein-2, and spinophilin transcripts were unchanged. 
      There were some correlations with in vivo biochemical and behavioral indices, 
      including VGluT1 mRNA with reward-seeking behavior, and serotonin 1A receptor 
      mRNA with CSF cortisol. Early deprivation did not affect hippocampal volume. We 
      conclude that early deprivation in a nonhuman primate, in the absence of 
      subsequent stressors, has a long-term effect on the hippocampal expression of 
      genes implicated in synaptic function and plasticity. The reductions in GAP-43 
      and serotonin 1A receptor expressions are comparable with findings in mood 
      disorder, supporting the possibility that the latter reflect an early 
      developmental contribution to disease vulnerability. Equally, the negative 
      results suggest that other features of mood disorder, such as decreased 
      hippocampal volume and BDNF expression, are related to different aspects of the 
      pathophysiological process.
FAU - Law, Amanda J
AU  - Law AJ
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, 
      Oxfordshire OX3 7JX, UK.
FAU - Pei, Qi
AU  - Pei Q
FAU - Walker, Mary
AU  - Walker M
FAU - Gordon-Andrews, Helen
AU  - Gordon-Andrews H
FAU - Weickert, Cyndi Shannon
AU  - Weickert CS
FAU - Feldon, Joram
AU  - Feldon J
FAU - Pryce, Christopher R
AU  - Pryce CR
FAU - Harrison, Paul J
AU  - Harrison PJ
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 068856/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080709
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Synaptophysin)
RN  - 0 (Vesicular Glutamate Transport Protein 1)
RN  - 0 (Vesicular Inhibitory Amino Acid Transport Proteins)
RN  - 0 (neurabin)
RN  - 0 (vesicular GABA transporter)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Callithrix
MH  - Female
MH  - GAP-43 Protein/metabolism
MH  - *Gene Expression
MH  - Hippocampus/anatomy & histology/*physiology
MH  - Hydrocortisone/cerebrospinal fluid
MH  - Male
MH  - *Maternal Deprivation
MH  - Microfilament Proteins/metabolism
MH  - Microtubule-Associated Proteins/metabolism
MH  - Mood Disorders/*genetics/physiopathology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuronal Plasticity/*genetics
MH  - *Paternal Deprivation
MH  - RNA, Messenger/metabolism
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Reward
MH  - Synaptic Transmission
MH  - Synaptophysin/metabolism
MH  - Vesicular Glutamate Transport Protein 1/metabolism
MH  - Vesicular Inhibitory Amino Acid Transport Proteins/metabolism
PMC - PMC2669475
MID - UKMS2770
OID - NLM: UKMS2770
EDAT- 2008/07/11 09:00
MHDA- 2009/06/18 09:00
PMCR- 2009/11/01
CRDT- 2008/07/11 09:00
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2009/06/18 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 10.1038/npp.2008.106 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2009 May;34(6):1381-94. doi: 10.1038/npp.2008.106. Epub 
      2008 Jul 9.