PMID- 18615253
OWN - NLM
STAT- MEDLINE
DCOM- 20081203
LR  - 20080730
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 300
IP  - 7
DP  - 2008 Aug
TI  - Association between tumor necrosis factor-alpha gene promoter polymorphism at 
      position -308 and acne in Turkish patients.
PG  - 371-6
LID - 10.1007/s00403-008-0871-0 [doi]
AB  - Acne is a multifactorial, chronic inflammatory disease of pilosebaceous unit in 
      which cytokines have been implicated in the pathogenesis. Although it is thought 
      to be an inherited disease, there are limited data supporting the relevant 
      genetic elements. Tumor necrosis factor-alpha (TNF-alpha) is one of the 
      proinflammatory cytokines involved in the acne pathogenesis. Several 
      single-nucleotide polymorphisms (SNPs) have been identified in the human 
      TNF-alpha gene promoter. The polymorphism at position -308, which involves 
      substituting guanine (G) for adenine (A) (TNFA-308 G/A) has been linked to 
      increased susceptibility to several chronic inflammatory diseases. The aim of 
      this study was to determine the TNFA-308 G/A polymorphism in acne and to examine 
      whether there is a relationship between this polymorphism and disease 
      susceptibility. Exactly, 113 patients with acne and 114 healthy control subjects 
      were included in the study. Polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) assay was used for analysis of the TNFA-308 G/A 
      polymorphism. We found that the frequency of the TNFA-308 GA genotype was 
      statistically significantly increased in patients compared with healthy controls 
      (P < 0.001). There was no association between TNFA genotypes and severity of acne 
      (P > 0.05). There was also no significant difference between male and female 
      patients. Our results suggest that TNFA-308 G/A polymorphism may contribute to a 
      predisposition to acne in Turkish population.
FAU - Baz, Kiymet
AU  - Baz K
AD  - Department of Dermatology, School of Medicine, Mersin University, Mersin, Turkey. 
      drkbaz@hotmail.com
FAU - Emin Erdal, M
AU  - Emin Erdal M
FAU - Yazici, Ayca Cordan
AU  - Yazici AC
FAU - Soylemez, Fatma
AU  - Soylemez F
FAU - Guvenc, Ulas
AU  - Guvenc U
FAU - Tasdelen, Bahar
AU  - Tasdelen B
FAU - Ikizoglu, Guliz
AU  - Ikizoglu G
LA  - eng
PT  - Journal Article
DEP - 20080710
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acne Vulgaris/*genetics/immunology
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics/immunology
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Tumor Necrosis Factor-alpha/*genetics/immunology
MH  - Turkey
EDAT- 2008/07/11 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/11 09:00
PHST- 2007/12/12 00:00 [received]
PHST- 2008/06/14 00:00 [accepted]
PHST- 2008/06/09 00:00 [revised]
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
AID - 10.1007/s00403-008-0871-0 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2008 Aug;300(7):371-6. doi: 10.1007/s00403-008-0871-0. Epub 
      2008 Jul 10.