PMID- 18615853
OWN - NLM
STAT- MEDLINE
DCOM- 20081112
LR  - 20221207
IS  - 1520-7552 (Print)
IS  - 1520-7552 (Linking)
VI  - 24
IP  - 6
DP  - 2008 Sep
TI  - Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a 
      case-control study of a Chinese Han population.
PG  - 480-5
LID - 10.1002/dmrr.882 [doi]
AB  - BACKGROUND: Previous investigations of the protein kinase C zeta (PRKCZ) gene, a 
      susceptibility factor for type 2 diabetes mellitus (T2DM), have focussed on its 
      single nucleotide polymorphisms (SNPs). In a departure from these earlier 
      studies, we tested six tagging markers of PRKCZ based on the Hapmap database to 
      evaluate their association with T2DM. METHODS: PCR-RFLP was performed to test the 
      genotypes in type 2 diabetes patients (n = 343) and normal controls (n = 429). 
      Insulin-related indexes were calculated from levels of fasting plasma insulin 
      (FPI) and fasting plasma glucose (FPG). RESULTS: The variant genotypes, 
      rs3753242TT, rs2503706CT, rs2503706CT/ TT and rs262654TT were associated with 
      T2DM. And the significance remained for rs3753242 TT (p < 0.001) after the false 
      discovery rate (FDR) correction. There was a doubling in the prevalence of the 
      TTGCCC haplotype in the case subjects (14.2%) compared with the control subjects 
      (6.9%) [OR (95% CI) = 2.19(1.49-3.22)]. In the control group, none of the 
      haplotypes studied was associated with insulin-related indexes. CONCLUSIONS: The 
      PRKCZ gene variants associated with the development of T2DM in this study must be 
      investigated in a larger population to reveal any potential effects on 
      metabolism.
FAU - Qin, Lei
AU  - Qin L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Nanjing 
      Medical University, Nanjing, Jiangsu Province, China.
FAU - Zhou, Ling
AU  - Zhou L
FAU - Wu, Xueji
AU  - Wu X
FAU - Cheng, Jinluo
AU  - Cheng J
FAU - Wang, Jingsong
AU  - Wang J
FAU - Du, Yunfeng
AU  - Du Y
FAU - Hu, Jihong
AU  - Hu J
FAU - Shen, Moyu
AU  - Shen M
FAU - Zhou, Jinyi
AU  - Zhou J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (DNA Primers)
RN  - EC 2.7.11.1 (protein kinase C zeta)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - DNA Primers
MH  - Diabetes Mellitus, Type 2/enzymology/epidemiology/*genetics/metabolism
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Interviews as Topic
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Kinase C/*genetics
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2008/07/11 09:00
MHDA- 2008/11/13 09:00
CRDT- 2008/07/11 09:00
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/11/13 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
AID - 10.1002/dmrr.882 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2008 Sep;24(6):480-5. doi: 10.1002/dmrr.882.