PMID- 18616070
OWN - NLM
STAT- MEDLINE
DCOM- 20080923
LR  - 20131121
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 14
IP  - 4
DP  - 2008 Jul-Aug
TI  - Melatonin for the treatment of gastroesophageal reflux disease.
PG  - 54-8
AB  - The enterochromaffin cells of the gastrointestinal (GI) tract secrete 400 times 
      as much melatonin as the pineal gland; therefore, it is not surprising that 
      research is finding that this indole plays an important role in GI functioning. 
      In animal studies, it protects against GI ulcerations, and randomized clinical 
      trials suggest its efficacy in treating functional dyspepsia and irritable bowel 
      syndrome. Melatonin administration has been shown to protect against esophageal 
      lesions in animals. Moreover, in a randomized, single-blind clinical trial of 
      subjects with gastroesophageal reflux disease (GERD), the combination of 
      melatonin with other natural supplements was found to be superior to omeprazole, 
      a proton pump inhibitor (PPI). Its administration as a single treatment for GERD 
      has not been previously reported. A 64-year-old Caucasian female who required 
      treatment with a PPI for symptoms of GERD wished to substitute a natural 
      treatment because of the risk of worsening her osteoporosis. She experienced a 
      return of symptoms following each of three 20-day trials of a proprietary blend 
      of D-limonene when attempts were made to discontinue the PPI. She then underwent 
      a trial of a natural formula consisting of melatonin 6 mg, 5-hydroxytryptophan 
      100 mg, D,L-methionine 500 mg, betaine 100 mg, L-taurine 50 mg, riboflavin 1.7 
      mg, vitamin B6 0.8 mg, folic acid 400 microg, and calcium 50 mg. After 40 days, 
      the PPI was withdrawn without a return of symptoms. Subsequently, an attempt to 
      reduce melatonin to 3 mg resulted in symptoms, while all other ingredients were 
      withdrawn with minimal symptoms during 10 months of follow-up.
FAU - Werbach, Melvyn R
AU  - Werbach MR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 0 (Amino Acids)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Vitamins)
RN  - JL5DK93RCL (Melatonin)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Aged
MH  - Amino Acids/administration & dosage
MH  - Anti-Ulcer Agents/*administration & dosage
MH  - Antioxidants/*administration & dosage
MH  - Dietary Supplements
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/prevention & control
MH  - Humans
MH  - Melatonin/*administration & dosage
MH  - Omeprazole/administration & dosage
MH  - Proton Pump Inhibitors
MH  - Treatment Outcome
MH  - Vitamins/administration & dosage
RF  - 33
EDAT- 2008/07/12 09:00
MHDA- 2008/09/24 09:00
CRDT- 2008/07/12 09:00
PHST- 2008/07/12 09:00 [pubmed]
PHST- 2008/09/24 09:00 [medline]
PHST- 2008/07/12 09:00 [entrez]
PST - ppublish
SO  - Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8.