PMID- 18618217
OWN - NLM
STAT- MEDLINE
DCOM- 20080909
LR  - 20211020
IS  - 1591-8890 (Print)
IS  - 1591-8890 (Linking)
VI  - 8
IP  - 2
DP  - 2008 Jun
TI  - DNA damage in lymphocytes and buccal mucosa cells of children with malignant 
      tumours undergoing chemotherapy.
PG  - 79-85
LID - 10.1007/s10238-008-0161-3 [doi]
AB  - The aim of the present study was to evaluate DNA damage (micronucleus) in 
      cytokinesis-blocked lymphocytes and exfoliated buccal mucosa cells from children 
      with malignant tumours and under chemotherapy. Micronucleated cells (MNCs) were 
      assessed from children before and during chemotherapy. A total of 21 healthy 
      children (controls), matched for gender and age, were used as control. The 
      results pointed out higher frequencies of micronucleated lymphocytes in children 
      with malignant tumour before any therapy when compared to healthy probands. 
      Furthermore an increase of micronucleated lymphocytes during chemotherapy was 
      detected when compared to the data obtained before chemotherapy. No statistically 
      significant increases of MNCs were noticed in buccal mucosa cells at any of the 
      timepoints evaluated. Taken together, these data indicate that the presence of 
      malignant tumours may increase the frequency of DNA damage in circulating 
      lymphocytes, these cells being more sensitive for detecting chromosome 
      aberrations caused by anti-cancer drugs.
FAU - Minicucci, E M
AU  - Minicucci EM
AD  - Department of Pathology, Faculty of Medicine, Botucatu Medical School, UNESP, 
      18618-000, Botucatu, SP, Brazil.
FAU - Ribeiro, D A
AU  - Ribeiro DA
FAU - de Camargo, B
AU  - de Camargo B
FAU - Costa, M C
AU  - Costa MC
FAU - Ribeiro, L R
AU  - Ribeiro LR
FAU - Favero Salvadori, D M
AU  - Favero Salvadori DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080711
PL  - Italy
TA  - Clin Exp Med
JT  - Clinical and experimental medicine
JID - 100973405
SB  - IM
CIN - Clin Exp Med. 2009 Mar;9(1):77-8; author reply 79-80. PMID: 18989736
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *DNA Damage
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lymphocytes/*ultrastructure
MH  - Male
MH  - Micronuclei, Chromosome-Defective
MH  - Mouth Mucosa/*ultrastructure
MH  - Neoplasms/*drug therapy/genetics
MH  - Smoking/adverse effects
EDAT- 2008/07/12 09:00
MHDA- 2008/09/10 09:00
CRDT- 2008/07/12 09:00
PHST- 2007/08/30 00:00 [received]
PHST- 2007/12/11 00:00 [accepted]
PHST- 2008/07/12 09:00 [pubmed]
PHST- 2008/09/10 09:00 [medline]
PHST- 2008/07/12 09:00 [entrez]
AID - 10.1007/s10238-008-0161-3 [doi]
PST - ppublish
SO  - Clin Exp Med. 2008 Jun;8(2):79-85. doi: 10.1007/s10238-008-0161-3. Epub 2008 Jul 
      11.