PMID- 18618243
OWN - NLM
STAT- MEDLINE
DCOM- 20090511
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 34
IP  - 3
DP  - 2009 Mar
TI  - The effects of caffeine on L-arginine metabolism in the brain of rats.
PG  - 395-9
LID - 10.1007/s11064-008-9790-x [doi]
AB  - In our study, the short-term effects of caffeine on L-arginine metabolism in the 
      brains of rats were investigated. Caffeine was given orally at two different 
      doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). Brain tissue arginase 
      activity in rats from the caffeine-treated groups decreased significantly 
      compared with the control group. Malondialdehyde (MDA) levels in the brain tissue 
      and serum of animals in the caffeine groups also decreased significantly. Brain 
      tissue and serum nitric oxide (NO) levels increased significantly after caffeine 
      administration. Tumor necrosis factor-alpha (TNF-alpha) levels were also 
      investigated in rat serum, but there was no statistically significant difference 
      between the TNF-alpha levels of the caffeine-treated rats groups and the control 
      rats. Our study indicates that brain arginase activity decreases after caffeine 
      administration at doses of 30 mg/kg and 100 mg/kg. As a result, we can say that 
      arginine induces production of NO in the organism.
FAU - Ofluoglu, Ebru
AU  - Ofluoglu E
AD  - Faculty of Medicine, Department of Medical Biochemistry, Gazi University, 
      Besevler, Ankara 06510, Turkey. ebruofluoglu@yahoo.com
FAU - Pasaoglu, Hatice
AU  - Pasaoglu H
FAU - Pasaoglu, Aydin
AU  - Pasaoglu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080710
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Central Nervous System Stimulants)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3G6A5W338E (Caffeine)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Animals
MH  - Arginase/metabolism
MH  - Arginine/*metabolism
MH  - Brain/*drug effects/metabolism
MH  - Caffeine/*pharmacology
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Male
MH  - Nitric Oxide/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2008/07/12 09:00
MHDA- 2009/05/12 09:00
CRDT- 2008/07/12 09:00
PHST- 2007/07/07 00:00 [received]
PHST- 2008/06/19 00:00 [accepted]
PHST- 2008/07/12 09:00 [pubmed]
PHST- 2009/05/12 09:00 [medline]
PHST- 2008/07/12 09:00 [entrez]
AID - 10.1007/s11064-008-9790-x [doi]
PST - ppublish
SO  - Neurochem Res. 2009 Mar;34(3):395-9. doi: 10.1007/s11064-008-9790-x. Epub 2008 
      Jul 10.