PMID- 18620024
OWN - NLM
STAT- MEDLINE
DCOM- 20081218
LR  - 20220317
IS  - 0306-4522 (Print)
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 155
IP  - 3
DP  - 2008 Aug 26
TI  - Docosahexaenoic acid dietary supplementation enhances the effects of exercise on 
      synaptic plasticity and cognition.
PG  - 751-9
LID - 10.1016/j.neuroscience.2008.05.061 [doi]
AB  - Omega-3 fatty acids (i.e. docosahexaenoic acid; DHA), similar to exercise, 
      improve cognitive function, promote neuroplasticity, and protect against 
      neurological lesion. In this study, we investigated a possible synergistic action 
      between DHA dietary supplementation and voluntary exercise on modulating synaptic 
      plasticity and cognition. Rats received DHA dietary supplementation (1.25% DHA) 
      with or without voluntary exercise for 12 days. We found that the DHA-enriched 
      diet significantly increased spatial learning ability, and these effects were 
      enhanced by exercise. The DHA-enriched diet increased levels of pro-brain-derived 
      neurotrophic factor (BDNF) and mature BDNF, whereas the additional application of 
      exercise boosted the levels of both. Furthermore, the levels of the activated 
      forms of CREB and synapsin I were incremented by the DHA-enriched diet with 
      greater elevation by the concurrent application of exercise. While the DHA diet 
      reduced hippocampal oxidized protein levels, a combination of a DHA diet and 
      exercise resulted in a greater reduction rate. The levels of activated forms of 
      hippocampal Akt and CaMKII were increased by the DHA-enriched diet, and with even 
      greater elevation by a combination of diet and exercise. Akt and CaMKII signaling 
      are crucial step by which BDNF exerts its action on synaptic plasticity and 
      learning and memory. These results indicate that the DHA diet enhanced the 
      effects of exercise on cognition and BDNF-related synaptic plasticity, a capacity 
      that may be used to promote mental health and reduce risk of neurological 
      disorders.
FAU - Wu, A
AU  - Wu A
AD  - Department of Physiological Science, University of California at Los Angeles, 621 
      Charles E. Young Drive, Los Angeles, CA 90095, USA.
FAU - Ying, Z
AU  - Ying Z
FAU - Gomez-Pinilla, F
AU  - Gomez-Pinilla F
LA  - eng
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - NS50465/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080617
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CREB-Binding Protein/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
MH  - Cognition/*drug effects/physiology
MH  - *Dietary Supplements
MH  - Docosahexaenoic Acids/*administration & dosage
MH  - Maze Learning/drug effects
MH  - Models, Biological
MH  - Neuronal Plasticity/*drug effects
MH  - Oxidative Stress/drug effects
MH  - *Physical Conditioning, Animal
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Time Factors
PMC - PMC3208643
MID - NIHMS68592
EDAT- 2008/07/16 09:00
MHDA- 2008/12/19 09:00
PMCR- 2011/11/04
CRDT- 2008/07/16 09:00
PHST- 2008/04/11 00:00 [received]
PHST- 2008/05/20 00:00 [revised]
PHST- 2008/05/20 00:00 [accepted]
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2008/12/19 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
PHST- 2011/11/04 00:00 [pmc-release]
AID - S0306-4522(08)00780-X [pii]
AID - 10.1016/j.neuroscience.2008.05.061 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Aug 26;155(3):751-9. doi: 10.1016/j.neuroscience.2008.05.061. 
      Epub 2008 Jun 17.