PMID- 18620413 OWN - NLM STAT- MEDLINE DCOM- 20081006 LR - 20121115 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 56 IP - 16 DP - 2008 Aug 27 TI - Cooking decreases observed perfluorinated compound concentrations in fish. PG - 7551-9 LID - 10.1021/jf800827r [doi] AB - Dietary intake is a major route of exposure to perfluorinated compounds (PFCs). Although fish and seafood contribute significantly to total dietary exposure to these compounds, there is uncertainty with respect to the effect of cooking on PFC concentrations in these foods. Eighteen fish species purchased from markets in Toronto, Mississauga, and Ottawa, Canada were analyzed for perfluorooctanesulfonamide (PFOSAs)-based fluorochemicals and perfluorinated acids (PFAs) in raw and cooked (baked, boiled, fried) samples. Of 17 analytes, perfluorooctanesulfonic acid (PFOS) was detected most frequently; concentrations ranged from 0.21 to 1.68 ng/g ww in raw and cooked samples. PFOSAs were detected only in scallops at concentrations ranging from 0.20 ng/g ww to 0.76 ng/g ww. Total concentrations of PFAs in samples were 0.21 to 9.20 ng/g ww, respectively, consistent with previous studies. All cooking methods reduced PFA concentrations. Baking appeared to be the most effective cooking method; after baking samples for 15 min at 163 C (325 degrees F), PFAs were not detected in any of the samples. The margin of exposures (MOE) between the toxicological points of reference and the dietary intake of perfluorocarboxylates (PFCAs) and PFOS in fish and seafood muscle tissue were greater than 4 orders of magnitude. This indicates that reducing consumption of fish muscle tissue is not warranted on the basis of PFC exposure concerns at the reported levels of contamination, even for high fish consuming populations. FAU - Del Gobbo, Liana AU - Del Gobbo L AD - Environmental Chemistry Research Group, Department of Geography, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3. FAU - Tittlemier, Sheryl AU - Tittlemier S FAU - Diamond, Miriam AU - Diamond M FAU - Pepper, Karen AU - Pepper K FAU - Tague, Brett AU - Tague B FAU - Yeudall, Fiona AU - Yeudall F FAU - Vanderlinden, Loren AU - Vanderlinden L LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080712 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 0 (Fluorocarbons) RN - 0 (Sulfonamides) RN - 80AM718FML (perfluorooctanesulfonamide) SB - IM MH - Animals MH - *Fishes MH - Fluorocarbons/*analysis MH - Food Contamination/analysis MH - *Hot Temperature MH - Meat/analysis MH - Muscles/chemistry MH - Seafood/*analysis MH - Sulfonamides/*analysis EDAT- 2008/07/16 09:00 MHDA- 2008/10/07 09:00 CRDT- 2008/07/16 09:00 PHST- 2008/07/16 09:00 [pubmed] PHST- 2008/10/07 09:00 [medline] PHST- 2008/07/16 09:00 [entrez] AID - 10.1021/jf800827r [doi] PST - ppublish SO - J Agric Food Chem. 2008 Aug 27;56(16):7551-9. doi: 10.1021/jf800827r. Epub 2008 Jul 12.