PMID- 18621091
OWN - NLM
STAT- MEDLINE
DCOM- 20090203
LR  - 20211020
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 32
IP  - 7
DP  - 2008 Oct 1
TI  - Effect of BDNF val66met polymorphism on age-related amygdala volume changes in 
      healthy subjects.
PG  - 1652-5
LID - 10.1016/j.pnpbp.2008.06.009 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of 
      age-related regional brain volumetric changes. Healthy volunteers with the valine 
      to methionine polymorphism at codon 66 of the BDNF gene (val66met) exhibit 
      decreased volume of a number of brain structures, including hippocampus, temporal 
      and occipital lobar gray matter volumes, and a negative correlation between age 
      and the volume of bilateral dorsolateral prefrontal cortices. We sought to 
      characterize the relationship between age, BDNF and amygdala volumes among 
      healthy volunteers. We measured amygdala volumes in 55 healthy, right-handed 
      volunteers who underwent structural magnetic resonance imaging (MRI) and were 
      also characterized demographically and genotyped with respect to BDNF. Using an 
      ANCOVA model, we found that amygdala volumes were inversely correlated with age 
      in BDNF val66met carriers but not in non-carriers. This is the first report of 
      age-related BDNF val66met polymorphism effects on amygdala volume.
FAU - Sublette, M E
AU  - Sublette ME
AD  - Department of Molecular Imaging and Neuropathology, New York State Psychiatric 
      Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 
      10032, USA. es2316@columbia.edu
FAU - Baca-Garcia, Enrique
AU  - Baca-Garcia E
FAU - Parsey, Ramin V
AU  - Parsey RV
FAU - Oquendo, Maria A
AU  - Oquendo MA
FAU - Rodrigues, Sarina M
AU  - Rodrigues SM
FAU - Galfalvy, Hanga
AU  - Galfalvy H
FAU - Huang, Yung-Yu
AU  - Huang YY
FAU - Arango, Victoria
AU  - Arango V
FAU - Mann, J J
AU  - Mann JJ
LA  - eng
GR  - MH016434/MH/NIMH NIH HHS/United States
GR  - T32 MH016434/MH/NIMH NIH HHS/United States
GR  - MH62185/MH/NIMH NIH HHS/United States
GR  - P50 MH062185/MH/NIMH NIH HHS/United States
GR  - P50 MH062185-08/MH/NIMH NIH HHS/United States
GR  - T32 MH016434-27/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080624
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - *Aging
MH  - Amygdala/*anatomy & histology
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Regression Analysis
MH  - Valine/*genetics
PMC - PMC2674019
MID - NIHMS70732
EDAT- 2008/07/16 09:00
MHDA- 2009/02/04 09:00
PMCR- 2009/10/01
CRDT- 2008/07/16 09:00
PHST- 2008/03/19 00:00 [received]
PHST- 2008/06/02 00:00 [revised]
PHST- 2008/06/18 00:00 [accepted]
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2009/02/04 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
PHST- 2009/10/01 00:00 [pmc-release]
AID - S0278-5846(08)00190-5 [pii]
AID - 10.1016/j.pnpbp.2008.06.009 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1652-5. doi: 
      10.1016/j.pnpbp.2008.06.009. Epub 2008 Jun 24.