PMID- 18621447
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20221207
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Apr
TI  - The R219K polymorphism in the ATP-binding cassette transporter 1 gene has a 
      protective effect on atherothrombotic cerebral infarction in Chinese Han ethnic 
      population.
PG  - 647-53
LID - 10.1016/j.neurobiolaging.2008.05.032 [doi]
AB  - The association of R219K and V825I polymorphisms of ABCA1 gene with cerebral 
      infarction has been rarely reported. Here we wish to address this issue. A total 
      of 476 subjects from Chinese Han ethnic population were investigated, including 
      152 control individuals and 324 patients with cerebral infarction. Genotyping of 
      R219K and V825I were performed by PCR-RFLP analysis. Data were analyzed using a 
      statistical package. The R219K genotype frequency distributions were 
      significantly different between patients with atherothrombotic cerebral 
      infarction (ACI) and control individuals, with fewer KK genotypes and more RR 
      genotypes in ACI patients (chi(2)=9.89, P<0.01). The K allele is less frequent 
      among ACI patients than in controls (chi(2)=9.16, P<0.005). A significant 
      association of KK with decreased ACI risk was exhibited, especially in male 
      patients, aged patients and individuals with hypertension. These results indicate 
      that the K allele of R219K polymorphism is an independent protective factor 
      against ACI. In addition, though there is no association of V825I with ACI, this 
      polymorphism may have certain synergistic effect with hypertension in 
      susceptibility to ACI.
CI  - Copyright (c) 2008 Elsevier Inc. All rights reserved.
FAU - Wang, Ning
AU  - Wang N
AD  - Department of Neurology and Institute of Neurology, First Affiliated Hospital, 
      Center of Neuroscience, Fujian Medical University, 20 Chazhong Road, Fuzhou 
      350005, China.
FAU - Xue, Xie-Hua
AU  - Xue XH
FAU - Lin, Yi
AU  - Lin Y
FAU - Fang, Ling
AU  - Fang L
FAU - Murong, Shenxing
AU  - Murong S
FAU - Wu, Zhi-Ying
AU  - Wu ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080714
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - ATP Binding Cassette Transporter 1
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Cerebral Infarction/ethnology/*genetics/metabolism
MH  - China/ethnology
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications/genetics/physiopathology
MH  - Intracranial Arteriosclerosis/ethnology/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Sex Distribution
EDAT- 2008/07/16 09:00
MHDA- 2010/06/09 06:00
CRDT- 2008/07/16 09:00
PHST- 2007/11/30 00:00 [received]
PHST- 2008/04/29 00:00 [revised]
PHST- 2008/05/28 00:00 [accepted]
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - S0197-4580(08)00179-6 [pii]
AID - 10.1016/j.neurobiolaging.2008.05.032 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2010 Apr;31(4):647-53. doi: 
      10.1016/j.neurobiolaging.2008.05.032. Epub 2008 Jul 14.