PMID- 18622811
OWN - NLM
STAT- MEDLINE
DCOM- 20080924
LR  - 20081019
IS  - 1525-6073 (Electronic)
IS  - 0742-0528 (Linking)
VI  - 25
IP  - 4
DP  - 2008 Jul
TI  - Circadian rhythms of C-FOS expression in the suprachiasmatic nuclei of the common 
      vole (Microtus arvalis).
PG  - 481-99
LID - 10.1080/07420520802254403 [doi]
AB  - The suprachiasmatic nuclei of the hypothalamus (SCN) are the master circadian 
      clock in mammals. Transcriptional activity in this master clock has a marker in 
      the immediate-early gene c-Fos. Within the SCN, distinct differences in c-Fos in 
      the ventrolateral and the dorsomedial SCN have been reported for rodent species 
      such as rats, mice, and hamsters. We studied C-FOS expression in the common vole 
      (Microtus arvalis) SCN under LD 12:12 h and under constant dim light conditions. 
      In the vole dorsomedial SCN, rhythmic C-FOS expression was seen in LD with a 
      clear peak in the middle of the light period. Under constant dim light, we report 
      constitutive, non-rhythmic expression of C-FOS in the dorsomedial SCN. This 
      pattern is consistent with the circadian organization of behavioral activity, 
      which is weak in voles and may be lost under constant dim-light conditions. In 
      the ventrolateral SCN, we observed a rise in C-FOS expression under LD conditions 
      prior to lights-on, followed by peak expression at lights-on. Another peak was 
      seen at lights-off. In an additional experiment, we subjected animals to LD 16:8 
      to test the hypothesis that the dawn and dusk peaks in ventrolateral C-FOS 
      expression change phase along with the photoperiod. The peak in C-FOS expression 
      did not shift with the time of lights on, but remained at the same external time 
      6. The results are consistent with the interpretation that in the vole, c-Fos 
      expression reports transcriptional activity associated more likely with an 
      internal, gating process than with an external effect of light.
FAU - van der Veen, Daan R
AU  - van der Veen DR
AD  - Department of Chronobiology, University of Groningen, Haren, The Netherlands. 
      d.veen@surrey.ac.uk
FAU - van der Pol-Meijer, Margriet M Th
AU  - van der Pol-Meijer MM
FAU - Jansen, Koen
AU  - Jansen K
FAU - Smeets, Maarten
AU  - Smeets M
FAU - van der Zee, Eddy A
AU  - van der Zee EA
FAU - Gerkema, Menno P
AU  - Gerkema MP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Arvicolinae
MH  - Biological Clocks
MH  - *Circadian Rhythm
MH  - Gene Expression Regulation
MH  - Immunohistochemistry/methods
MH  - Light
MH  - Mice
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - Rats
MH  - Suprachiasmatic Nucleus/*metabolism
MH  - Time Factors
MH  - Transcription, Genetic
EDAT- 2008/07/16 09:00
MHDA- 2008/09/25 09:00
CRDT- 2008/07/16 09:00
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2008/09/25 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - 794929622 [pii]
AID - 10.1080/07420520802254403 [doi]
PST - ppublish
SO  - Chronobiol Int. 2008 Jul;25(4):481-99. doi: 10.1080/07420520802254403.