PMID- 18622878
OWN - NLM
STAT- MEDLINE
DCOM- 20090901
LR  - 20131121
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 20
IP  - 1
DP  - 2009
TI  - Ibuprofen slow-release foam dressing reduces wound pain in painful exuding 
      wounds: preliminary findings from an international real-life study.
PG  - 19-26
LID - 10.1080/09546630802178232 [doi]
AB  - BACKGROUND: Wound pain is a serious problem for people with chronic wounds. The 
      aim of this real-life study was to compare the effect of a foam dressing that 
      releases ibuprofen (Biatain Ibu) with local best practice on the treatment of 
      painful exuding wounds. METHODS: A total of 185 patients with painful exuding 
      wounds were randomized to either ibuprofen foam treatment (n = 98) or local best 
      practice (n = 87). The primary endpoint was pain relief over 7 days of treatment, 
      assessed daily using a 5-point verbal rating scale (no relief, slight relief, 
      moderate relief, lots of relief, and complete relief). Secondary endpoints 
      included a total reduction in pain intensity for the whole study period (using an 
      11-point Numeric Box Scale: 0 = no pain to 10 = worst possible pain) and 
      incidence of adverse events (AEs). RESULTS: More patients in the ibuprofen foam 
      treatment group reported wound pain relief and lower wound pain intensity values 
      after 7 days (p < 0.0001 for both variables). Within the four most common ulcer 
      aetiolgies, patients reported significantly more effective pain relief with 
      ibuprofen foam treatment (venous: p = 0.009, mixed arterial venous: p < 0.0001, 
      arterial: p = 0.0009, and vasculitis: p = 0.009). In all groups, patients from 
      the ibuprofen foam group reported lower pain intensities. The results were 
      significant for patients with venous (p < 0.002) and arterial (p < 0.0001) leg 
      ulcers. Two AEs were reported. CONCLUSIONS: The ibuprofen foam represents an 
      effective and safe alternative to local best practice in the management of 
      painful exuding wounds.
FAU - Romanelli, Marco
AU  - Romanelli M
AD  - m.romanelli@med.unipi.it
FAU - Dini, Valentina
AU  - Dini V
FAU - Polignano, Roberto
AU  - Polignano R
FAU - Bonadeo, Piero
AU  - Bonadeo P
FAU - Maggio, Giulio
AU  - Maggio G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Delayed-Action Preparations)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Delayed-Action Preparations/*pharmacology/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Ibuprofen/*pharmacology/therapeutic use
MH  - International Cooperation
MH  - Male
MH  - Middle Aged
MH  - *Occlusive Dressings
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Probability
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Skin Ulcer/diagnosis/*drug therapy
MH  - Treatment Outcome
MH  - Vasculitis/diagnosis/*drug therapy
MH  - Wounds and Injuries/diagnosis/drug therapy
EDAT- 2008/07/16 09:00
MHDA- 2009/09/02 06:00
CRDT- 2008/07/16 09:00
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2009/09/02 06:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - 794947107 [pii]
AID - 10.1080/09546630802178232 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2009;20(1):19-26. doi: 10.1080/09546630802178232.