PMID- 18622893
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20221207
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 40
IP  - 11
DP  - 2008 Nov
TI  - Reduced frequency of peripheral plasmacytoid dendritic cells in type 1 diabetes.
PG  - 767-71
LID - 10.1055/s-2008-1080896 [doi]
AB  - Dendritic cells (DCs) as antigen presenting cells play an important role in the 
      initiation of an autoimmune disease like type 1 diabetes. Although there is 
      evidence from the NOD mouse model that the function and frequency of DCs is 
      altered in type 1 diabetes, there is little data on dendritic cells in human type 
      1 diabetes. We investigated peripheral blood myeloid (mDC1 and mDC2) and 
      plasmacytoid dendritic cells (pDCs) in 15 type 1 diabetes patients with recent 
      onset (within the last 3 months) of type 1 diabetes as well as in 15 patients 
      with long standing (more than 5 years) type 1 diabetes by flow cytometry. Both 
      groups were compared to age matched controls. We observed a significantly reduced 
      percentage of pDCs of peripheral blood mononuclear cells (PBMCs) in both recent 
      onset (0.13 vs. 0.25%, p=0.01) and long standing type 1 diabetes patients (0.13 
      vs. 0.24%, p=0.01). The absolute counts of pDCs per ml of blood were also 
      significantly lower in both recent onset (mean 9560 vs. 13524, p=0.048) and 
      long-standing diabetes (mean 7869 vs. 12202; p=0.05). The percentage of mDC1 was 
      significantly diminished in recent onset (0.21% vs. 0.30%, p=0.034), but not in 
      long standing type 1 diabetes. Our study demonstrates a persisting reduction of 
      peripheral plasmacytoid DCs in type 1 diabetes patients. Since pDCs are involved 
      in the control of immune responses and inducing regulatory cells, a reduced 
      number of pDCs may predispose to an autoimmune reaction in the pancreatic islets.
FAU - Hinkmann, C
AU  - Hinkmann C
AD  - Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nurnberg, 
      Erlangen, Germany.
FAU - Knerr, I
AU  - Knerr I
FAU - Hahn, E-G
AU  - Hahn EG
FAU - Lohmann, T
AU  - Lohmann T
FAU - Seifarth, C C
AU  - Seifarth CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080711
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoimmunity
MH  - Cell Count
MH  - Child
MH  - Dendritic Cells/immunology/*pathology
MH  - Diabetes Mellitus, Type 1/blood/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Islets of Langerhans/immunology
MH  - Leukocyte Count
MH  - Leukocytes, Mononuclear/pathology
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 2008/07/16 09:00
MHDA- 2009/02/14 09:00
CRDT- 2008/07/16 09:00
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - 10.1055/s-2008-1080896 [doi]
PST - ppublish
SO  - Horm Metab Res. 2008 Nov;40(11):767-71. doi: 10.1055/s-2008-1080896. Epub 2008 
      Jul 11.