PMID- 18623981
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20110225
IS  - 1121-7138 (Print)
IS  - 1121-7138 (Linking)
VI  - 31
IP  - 2
DP  - 2008 Apr
TI  - Non-organ-specific autoantibodies in renal transplant recipients: relation to BK 
      virus infection.
PG  - 175-80
AB  - Polyomavirus BK reactivation is common in renal transplant recipients and may 
      cause nephropathy with significant graft dysfunction. The induction of 
      anti-double stranded DNA (anti-dsDNA) antibodies by BKV has been described in 
      experimental animals and during primary infection, and has been implicated in the 
      pathogenesis of systemic lupus erythematosus. This study evaluated the occurrence 
      of anti-dsDNA antibodies and non-organ-specific autoantibodies (NOSA) by indirect 
      immunofluorescence before transplantation and at 3 and 6 months 
      post-transplantation in 90 renal transplant recipients and the association with 
      BKV reactivation, demographic and clinical features. Moreover, the relation to 
      HCMV infection, as detected by pp65-antigenemia, was also evaluated. 
      Post-transplantation NOSAs were present in 23/90 (25.6%) and anti-dsDNA 
      antibodies in 17/90 (18.9%). BK viremia was detected in at least one serum sample 
      in 22 patients: 9 anti-dsDNA antibody-positive vs 13 negative (p<0.01). No 
      significant correlation between the occurrence of NOSAs and anti-dsDNA antibodies 
      and demographic and clinical features was found. No significant association with 
      pp65-antigenemia-positivity was found, although antigenemia was positive in 6/23 
      NOSA-positive patients (26.1%). Although a relation seems to exist between BKV 
      and the occurrence of anti-dsDNA antibodies in renal transplant patients, the 
      lack of correlation with other epidemiological and clinical features does not 
      allow any conclusion. The role of autoimmune response in this context and the 
      relation with other patient-related factors and infectious agents should be 
      further investigated.
FAU - Costa, Cristina
AU  - Costa C
AD  - Department of Public Health and Microbiology, University of Turin, Turin, Italy. 
      cristina.costa@unito.it
FAU - Touscoz, Giovanni Antonio
AU  - Touscoz GA
FAU - Bergallo, Massimiliano
AU  - Bergallo M
FAU - Sidoti, Francesca
AU  - Sidoti F
FAU - Terlizzi, Maria Elena
AU  - Terlizzi ME
FAU - Astegiano, Sara
AU  - Astegiano S
FAU - Merlino, Chiara
AU  - Merlino C
FAU - Segoloni, Giuseppe P
AU  - Segoloni GP
FAU - Cavallo, Rossana
AU  - Cavallo R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - New Microbiol
JT  - The new microbiologica
JID - 9516291
RN  - 0 (Autoantibodies)
RN  - 0 (Phosphoproteins)
RN  - 0 (Viral Matrix Proteins)
RN  - 0 (cytomegalovirus matrix protein 65kDa)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*blood
MH  - BK Virus/*immunology
MH  - DNA/immunology
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Phosphoproteins/blood
MH  - Polyomavirus Infections/*immunology
MH  - Statistics as Topic
MH  - Tumor Virus Infections/*immunology
MH  - Viral Matrix Proteins/blood
MH  - Viremia
EDAT- 2008/07/16 09:00
MHDA- 2008/08/08 09:00
CRDT- 2008/07/16 09:00
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
PST - ppublish
SO  - New Microbiol. 2008 Apr;31(2):175-80.