PMID- 18625009
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20131121
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 53
IP  - 3
DP  - 2008 Aug
TI  - Quercetin but not luteolin suppresses the induction of lethal shock upon 
      infection of mice with Salmonella typhimurium.
PG  - 306-13
LID - 10.1111/j.1574-695X.2008.00398.x [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is important for the induction of 
      systemic inflammatory responses that lead to lethal shock. Quercetin and 
      luteolin, which differ by one hydroxyl group, are known to suppress the 
      lipopolysaccharide-induced production of TNF-alpha in vitro. We show differing 
      inhibitory effects of quercetin and luteolin on the induction of lethal shock in 
      Salmonella typhimurium aroA-infected mice. In a time- and dose-dependent manner, 
      quercetin reduced the plasma levels of TNF-alpha, lowered bacterial titers in 
      livers, prevented liver damage and prolonged survival, while luteolin had little 
      or no effect. Compared with luteolin, quercetin increased the infiltration of 
      Gr-1(+)CD69(+) neutrophils into the peritoneal cavity and lowered heat shock 
      protein 70 expression. Obviously, the additional hydroxyl group in quercetin is 
      important for suppressing infection-induced lethal shock in mice.
FAU - Sugiyama, Tsuyoshi
AU  - Sugiyama T
AD  - Department of Biosciences, Graduate School of Science, Kitasato University, 
      Kitasato, Sagamihara, Japan.
FAU - Kawaguchi, Kiichiro
AU  - Kawaguchi K
FAU - Dobashi, Hideki
AU  - Dobashi H
FAU - Miyake, Ryo
AU  - Miyake R
FAU - Kaneko, Masahiro
AU  - Kaneko M
FAU - Kumazawa, Yoshio
AU  - Kumazawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080709
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Immunologic Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9IKM0I5T1E (Quercetin)
RN  - KUX1ZNC9J2 (Luteolin)
SB  - IM
MH  - Animals
MH  - Colony Count, Microbial
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - HSP70 Heat-Shock Proteins/antagonists & inhibitors/biosynthesis
MH  - Immunologic Factors/*pharmacology
MH  - Liver/microbiology/pathology
MH  - Luteolin/*pharmacology
MH  - Mice
MH  - Molecular Structure
MH  - Neutrophils/immunology
MH  - Peritoneal Cavity/cytology
MH  - Quercetin/*pharmacology
MH  - Salmonella Infections, Animal/*complications/microbiology
MH  - Salmonella typhimurium/*isolation & purification
MH  - Shock/*prevention & control
MH  - Survival Analysis
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/blood
EDAT- 2008/07/16 09:00
MHDA- 2008/10/04 09:00
CRDT- 2008/07/16 09:00
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - FIM398 [pii]
AID - 10.1111/j.1574-695X.2008.00398.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2008 Aug;53(3):306-13. doi: 
      10.1111/j.1574-695X.2008.00398.x. Epub 2008 Jul 9.