PMID- 18625328
OWN - NLM
STAT- MEDLINE
DCOM- 20090116
LR  - 20131121
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 90
IP  - 3
DP  - 2008 Oct
TI  - BDNF reverses the CTA memory deficits produced by inhibition of protein 
      synthesis.
PG  - 584-7
LID - 10.1016/j.nlm.2008.06.003 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is an essential protein synthesis 
      product that has emerged as one of the most potent molecular mediators of not 
      only central synaptic plasticity, but also behavioral interactions between an 
      organism and its environment. Our previous studies on the insular cortex (IC), a 
      region of the temporal cortex implicated in the acquisition and storage of 
      conditioned taste aversion (CTA), have demonstrated that intracortical 
      microinfusion of BDNF induces a lasting potentiation of synaptic efficacy in the 
      projection from the basolateral nucleus of the amygdala (Bla) to the IC of adult 
      rats in vivo. Recently, we found that intracortical microinfusion of BDNF 
      previous to CTA training enhances the retention of this task. In this work, we 
      present experimental data showing that acute intracortical delivery of BDNF (2 
      microg/2 microl per side) reverses the deficit in CTA memory caused by inhibition 
      of insular cortex protein synthesis due to anisomycin administration (100 
      microg/microl per side) in male adult Wistar rats. These findings suggest that 
      BDNF is a protein synthesis product essential for neocortical long-term memory 
      storage.
FAU - Moguel-Gonzalez, Minerva
AU  - Moguel-Gonzalez M
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Av. Universidad 3004, 04510 Mexico D.F., 
      Mexico.
FAU - Gomez-Palacio-Schjetnan, Andrea
AU  - Gomez-Palacio-Schjetnan A
FAU - Escobar, Martha L
AU  - Escobar ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080729
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 6C74YM2NGI (Anisomycin)
SB  - IM
MH  - Animals
MH  - Anisomycin/pharmacology
MH  - Avoidance Learning/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*physiology
MH  - Conditioning, Classical/drug effects/*physiology
MH  - Male
MH  - Microinjections
MH  - Nerve Tissue Proteins/biosynthesis/drug effects
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction/drug effects/physiology
MH  - Taste
MH  - Temporal Lobe/drug effects/*physiology
EDAT- 2008/07/16 09:00
MHDA- 2009/01/17 09:00
CRDT- 2008/07/16 09:00
PHST- 2008/03/05 00:00 [received]
PHST- 2008/06/02 00:00 [revised]
PHST- 2008/06/15 00:00 [accepted]
PHST- 2008/07/16 09:00 [pubmed]
PHST- 2009/01/17 09:00 [medline]
PHST- 2008/07/16 09:00 [entrez]
AID - S1074-7427(08)00102-0 [pii]
AID - 10.1016/j.nlm.2008.06.003 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2008 Oct;90(3):584-7. doi: 10.1016/j.nlm.2008.06.003. Epub 
      2008 Jul 29.