PMID- 18627572
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 4
DP  - 2008 Oct
TI  - New insights of HLA class I association to Behcet's disease in Portuguese 
      patients.
PG  - 379-82
LID - 10.1111/j.1399-0039.2008.01087.x [doi]
AB  - Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with 
      Behcet's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I 
      alleles in BD susceptibility in a Portuguese population and its association with 
      disease severity, we studied 78 BD patients and 208 healthy controls. The 
      patients were classified into two severity groups as described by Gul et al. As 
      expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 
      alleles was significantly higher in patients. Regarding severity, HLA-B*27 
      frequency was higher in the severe group compared with controls and with the mild 
      group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this 
      patients. HLA-B*27 may be important as a prognostic factor.
FAU - Bettencourt, A
AU  - Bettencourt A
AD  - Immunogenetics Laboratory, Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), 
      Unidade Multidisciplinar de Investigacao Biomedica (UMIB), Porto, Portugal. 
      ambettencourt@icbas.up.pt
FAU - Pereira, C
AU  - Pereira C
FAU - Carvalho, L
AU  - Carvalho L
FAU - Carvalho, C
AU  - Carvalho C
FAU - Patto, J V
AU  - Patto JV
FAU - Bastos, M
AU  - Bastos M
FAU - Silva, A M
AU  - Silva AM
FAU - Barros, R
AU  - Barros R
FAU - Vasconcelos, C
AU  - Vasconcelos C
FAU - Paiva, P
AU  - Paiva P
FAU - Costa, L
AU  - Costa L
FAU - Costa, P P
AU  - Costa PP
FAU - Mendonca, D
AU  - Mendonca D
FAU - Correia, J
AU  - Correia J
FAU - Silva, B M
AU  - Silva BM
LA  - eng
PT  - Journal Article
DEP - 20080708
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (MAGEA1 protein, human)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, Neoplasm/*genetics
MH  - Behcet Syndrome/epidemiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-B51 Antigen
MH  - Humans
MH  - Male
MH  - Melanoma-Specific Antigens
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Portugal/epidemiology
EDAT- 2008/07/17 09:00
MHDA- 2009/05/19 09:00
CRDT- 2008/07/17 09:00
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
AID - TAN1087 [pii]
AID - 10.1111/j.1399-0039.2008.01087.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Oct;72(4):379-82. doi: 10.1111/j.1399-0039.2008.01087.x. 
      Epub 2008 Jul 8.