PMID- 18627625
OWN - NLM
STAT- MEDLINE
DCOM- 20080929
LR  - 20221207
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 7
DP  - 2008 Jul 15
TI  - Xenohormone transactivities are inversely associated to serum POPs in Inuit.
PG  - 38
LID - 10.1186/1476-069X-7-38 [doi]
AB  - BACKGROUND: The persistent organic pollutants (POPs) are highly lipophilic and 
      resistant to biodegradation and found in e.g. seafood and marine mammals. 
      Greenlandic Inuit have high intake of marine food and thus high POP burden that 
      varies according to local conditions and dietary preference. We do for the very 
      first time report the serum POP related non-steroidal xenohormone activity of 
      Inuit across Greenland. The aims were 1) to determine the integrated xenohormone 
      bioactivities as an exposure biomarker of the actual lipophilic serum POP mixture 
      measuring the effect on estrogen (ER) and androgen receptor (AR) transactivity in 
      citizens from different Greenlandic districts and 2) to evaluate associations to 
      serum POP markers (14 PCBs and 10 pesticides) and lifestyle characteristics. 
      METHODS: Serum samples from 121 men and 119 women from Nuuk, Sisimiut and Qaanaaq 
      were extracted using SPE-HPLC fractionation to obtain the serum POP fraction free 
      of endogenous hormones. The serum POP fraction was used for determination of 
      xenohormone transactivity using ER and AR reporter gene assays. RESULTS: In 
      overall, the xenohormone transactivities differed between districts as well as 
      between the genders. Associations between the transactivities and age, n-3/n-6 
      and smoker years were observed. The xenoestrogenic and xenoandrogenic 
      transactivities correlated negatively to the POPs for the combined female and 
      male data, respectively. CONCLUSION: The non-steroidal xenohormone 
      transactivities can be used as an integrated biomarker of POP exposure and 
      lifestyle characteristics. The actual serum POP mixtures antagonized the age 
      adjusted sex hormone receptor functions. Comparison of different study 
      populations requires in addition to age inclusion of diet and lifestyle factors.
FAU - Kruger, Tanja
AU  - Kruger T
AD  - Unit of Cellular and Molecular Toxicology, Centre for Arctic Environmental 
      Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 
      6, Build 1260, 8000 Aarhus C, Denmark. tk@mil.au.dk
FAU - Ghisari, Mandana
AU  - Ghisari M
FAU - Hjelmborg, Philip S
AU  - Hjelmborg PS
FAU - Deutch, Bente
AU  - Deutch B
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080715
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Chromatography, Gel
MH  - Chromatography, High Pressure Liquid
MH  - Environmental Pollutants/*blood/toxicity
MH  - Female
MH  - Humans
MH  - *Inuit
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Receptors, Androgen/drug effects
MH  - Receptors, Estrogen/drug effects
MH  - Xenobiotics/*blood/toxicity
PMC - PMC2503956
EDAT- 2008/07/17 09:00
MHDA- 2008/09/30 09:00
PMCR- 2008/07/15
CRDT- 2008/07/17 09:00
PHST- 2008/02/13 00:00 [received]
PHST- 2008/07/15 00:00 [accepted]
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/09/30 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
PHST- 2008/07/15 00:00 [pmc-release]
AID - 1476-069X-7-38 [pii]
AID - 10.1186/1476-069X-7-38 [doi]
PST - epublish
SO  - Environ Health. 2008 Jul 15;7:38. doi: 10.1186/1476-069X-7-38.