PMID- 18627903
OWN - NLM
STAT- MEDLINE
DCOM- 20081006
LR  - 20181201
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 253
IP  - 1-2
DP  - 2008 May-Jun
TI  - Immune effects of mesenchymal stem cells: implications for Charcot-Marie-Tooth 
      disease.
PG  - 11-5
LID - 10.1016/j.cellimm.2008.06.003 [doi]
AB  - Mesenchymal stem cell (MSC) therapy is the most clinically advanced form of cell 
      therapy, second to hematopoietic stem cell transplants. To date, MSC have been 
      used for immune modulation in conditions such as Graft Versus Host Disease (GVHD) 
      and Crohn's Disease, for which Phase III clinical trials are currently in 
      progress. Here, we review the immunological properties of MSC and make a case for 
      their use in treatment of Charcot-Marie-Tooth disease type 1 (CMT1), a group of 
      inherited peripheral neuropathies. CMT1 is characterized by demyelination and 
      aberrant immune activation making this condition an ideal target for exploration 
      of MSC therapy, given the ability of these cells to promote sheath regeneration 
      as well as suppress inflammation. Studies supporting this hypothesis will be 
      presented and placed into the context of other cell-based approaches that are 
      theoretically feasible. Given that MSCs selectively home to areas of 
      inflammation, as well as exert effects in an allogeneic manner, the possibility 
      of an "off the shelf" therapy for CMT1 will be discussed.
FAU - Leal, Alejandro
AU  - Leal A
AD  - School of Biology and Neuroscience Research Program, University of Costa Rica, 
      San Jose, Costa Rica, USA.
FAU - Ichim, Thomas E
AU  - Ichim TE
FAU - Marleau, Annette M
AU  - Marleau AM
FAU - Lara, Fabian
AU  - Lara F
FAU - Kaushal, Shalesh
AU  - Kaushal S
FAU - Riordan, Neil H
AU  - Riordan NH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080715
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
SB  - IM
MH  - Animals
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - *Charcot-Marie-Tooth Disease/immunology/therapy
MH  - Disease Models, Animal
MH  - Graft vs Host Disease/immunology/therapy
MH  - Humans
MH  - Immunity, Innate/physiology
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/*immunology
RF  - 75
EDAT- 2008/07/17 09:00
MHDA- 2008/10/07 09:00
CRDT- 2008/07/17 09:00
PHST- 2008/03/24 00:00 [received]
PHST- 2008/05/28 00:00 [revised]
PHST- 2008/06/04 00:00 [accepted]
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/10/07 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
AID - S0008-8749(08)00109-3 [pii]
AID - 10.1016/j.cellimm.2008.06.003 [doi]
PST - ppublish
SO  - Cell Immunol. 2008 May-Jun;253(1-2):11-5. doi: 10.1016/j.cellimm.2008.06.003. 
      Epub 2008 Jul 15.