PMID- 18628071
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20211020
IS  - 1699-048X (Print)
IS  - 1699-048X (Linking)
VI  - 10
IP  - 7
DP  - 2008 Jul
TI  - Could other viruses cause pediatric posttransplant lymphoproliferative disorder?
PG  - 422-5
AB  - INTRODUCTION: Posttransplant lymphoproliferative disorder (PTLD) constitutes a 
      heterogeneous group of diseases. We summarize the experience of our hospital, one 
      of Spain's largest series of renal (294), liver (47) and allogeneic stem cell 
      transplants (67), where four cases of PTLD have developed related to complex 
      viral infections. METHODS: Case 1 was a 24-month-old boy diagnosed with acute 
      lymphoblastic leukemia who underwent allogeneic stem-cell transplantation (SCT). 
      He was seropositive for Epstein-Barr virus (EBV) and developed an aggressive 
      Bcell non-Hodgkin's lymphoma (B-NHL) related to EBV reactivation and human 
      herpesvirus 6 (HHV-6) infection. Cases 2, 3, and 4 developed after kidney 
      transplantation and were all EBV seronegative. Case 2 had associated 
      cytomegalovirus (CMV) and EBV infection. Cases 3 and 4 only revealed EBV viral 
      load. Cases 1, 3, and 4 progressed rapidly, with fatal outcome. Global incidence 
      of PTLD in our series is 1.1%. CONCLUSION: PTLD is a rare but life-threatening 
      condition. Although EBV plays a clear role in its pathogenesis, other associated 
      viral infections could trigger this situation. Current therapies include 
      rituximab, decreasing immunosuppressive drugs. and conventional chemotherapy.
FAU - Vila, L
AU  - Vila L
AD  - Paediatric Oncology Unit, Hospital Infantil La Fe, Valencia, Spain.
FAU - Moreno, L
AU  - Moreno L
FAU - Andres, M M
AU  - Andres MM
FAU - Fernandez, J M
AU  - Fernandez JM
FAU - Verdeguer, A
AU  - Verdeguer A
FAU - Perez-Valle, S
AU  - Perez-Valle S
FAU - Sanguesa, C
AU  - Sanguesa C
FAU - Berbel, O
AU  - Berbel O
FAU - Castel, V
AU  - Castel V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - Clin Transl Oncol
JT  - Clinical & translational oncology : official publication of the Federation of 
      Spanish Oncology Societies and of the National Cancer Institute of Mexico
JID - 101247119
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus
MH  - Cytomegalovirus Infections/complications/epidemiology
MH  - Epstein-Barr Virus Infections/complications/epidemiology
MH  - Herpesvirus 4, Human
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Kidney Transplantation/adverse effects
MH  - Lymphoproliferative Disorders/*virology
MH  - Male
MH  - Postoperative Complications/*virology
MH  - Stem Cell Transplantation/adverse effects
MH  - Tumor Virus Infections/complications/epidemiology/*virology
MH  - Viral Load
MH  - Virus Diseases/*complications/epidemiology
EDAT- 2008/07/17 09:00
MHDA- 2008/10/15 09:00
CRDT- 2008/07/17 09:00
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
AID - CLAT63 [pii]
AID - 10.1007/s12094-008-0225-6 [doi]
PST - ppublish
SO  - Clin Transl Oncol. 2008 Jul;10(7):422-5. doi: 10.1007/s12094-008-0225-6.