PMID- 18628679
OWN - NLM
STAT- MEDLINE
DCOM- 20080828
LR  - 20080716
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 18
IP  - 4
DP  - 2008 Aug
TI  - Brain-derived neurotrophic factor polymorphisms and frontal cortex morphology in 
      schizophrenia.
PG  - 177-83
LID - 10.1097/YPG.0b013e3283050a94 [doi]
AB  - OBJECTIVE: To investigate associations between brain-derived neurotrophic factor 
      (BDNF) gene polymorphisms and regional frontal cortical thickness and volume in 
      patients with schizophrenia and healthy control participants. METHODS: BDNF 
      genotyping was performed using polymerase chain reaction and pyrosequencing 
      techniques in 96 patients with schizophrenia or schizoaffective disorder and 104 
      healthy control participants. Cortical morphology was analyzed by processing 
      magnetic resonance brain images with the FreeSurfer software package. General 
      linear model analysis was used to study associations between BDNF variants and 
      cortical thickness in patients and controls, respectively. Regional frontal 
      cortical volumes were defined from automatic cortical parcellations. RESULTS: For 
      patients with schizophrenia, there was an association between the BDNF -633 T/A 
      polymorphism and thickness and volume of distinct subregions of the prefrontal 
      cortex. Data indicated trends toward genotypic associations between the BDNF 270 
      C/T and 11757 G/C polymorphisms and the volume of specific frontal lobe regions 
      in patients with schizophrenia. Among controls, there were no significant 
      associations between BDNF polymorphisms and cortical thickness. Trends toward 
      genotypic associations between BDNF polymorphisms and volumes of some frontal 
      lobe regions for control participants were observed, although these differences 
      did not reach statistical significance. CONCLUSION: Polymorphisms in the BDNF 
      gene may be associated with variation in frontal lobe morphology. Associations 
      seem to be stronger in patients with schizophrenia than in healthy controls.
FAU - Varnas, Katarina
AU  - Varnas K
AD  - Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 
      SE-171 76 Stockholm, Sweden. katarina.varnas@ki.se
FAU - Lawyer, Glenn
AU  - Lawyer G
FAU - Jonsson, Erik G
AU  - Jonsson EG
FAU - Kulle, Bettina
AU  - Kulle B
FAU - Nesvag, Ragnar
AU  - Nesvag R
FAU - Hall, Hakan
AU  - Hall H
FAU - Terenius, Lars
AU  - Terenius L
FAU - Agartz, Ingrid
AU  - Agartz I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prefrontal Cortex/*pathology
MH  - Schizophrenia/*genetics/*pathology
EDAT- 2008/07/17 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/07/17 09:00
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
AID - 00041444-200808000-00005 [pii]
AID - 10.1097/YPG.0b013e3283050a94 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2008 Aug;18(4):177-83. doi: 10.1097/YPG.0b013e3283050a94.