PMID- 18629323
OWN - NLM
STAT- MEDLINE
DCOM- 20080912
LR  - 20211020
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 116
IP  - 7
DP  - 2008 Jul
TI  - Chronic traffic-related air pollution and stress interact to predict biologic and 
      clinical outcomes in asthma.
PG  - 970-5
LID - 10.1289/ehp.11076 [doi]
AB  - BACKGROUND: Previous research has documented effects of both physical and social 
      environmental exposures on childhood asthma. However, few studies have considered 
      how these two environments might interact to affect asthma. OBJECTIVE: This study 
      aimed to test interactions between chronic exposure to traffic-related air 
      pollution and chronic family stress in predicting biologic and clinical outcomes 
      in children with asthma. METHOD: Children with asthma (n = 73, 9-18 years of age) 
      were interviewed about life stress, and asthma-relevant inflammatory markers 
      [cytokine production, immunoglobulin E (IgE), eosinophil counts] were measured. 
      Parents reported on children's symptoms. Children completed daily diaries of 
      symptoms and peak expiratory flow rate (PEFR) measures at baseline and 6 months 
      later. Exposure to traffic-related air pollution was assessed using a land use 
      regression model for nitrogen dioxide concentrations. RESULTS: NO(2) by stress 
      interactions were found for interleukin-5 (beta for interaction term = -0.31, p = 
      0.02), IgE (interaction beta = -0.29, p = 0.02), and eosinophil counts 
      (interaction beta = -0.24, p = 0.04). These interactions showed that higher 
      chronic stress was associated with heightened inflammatory profiles as pollution 
      levels decreased. Longitudinally, NO(2) by stress interactions emerged for daily 
      diary symptoms (interaction beta = -0.28, p = 0.02), parent-reported symptoms 
      (interaction beta = -0.25, p = 0.07), and PEFR (interaction beta = 0.30, p = 
      0.03). These interactions indicated that higher chronic stress was associated 
      with increases over time in symptoms and decreases over time in PEFR as pollution 
      levels decreased. CONCLUSIONS: The physical and social environments interacted in 
      predicting both biologic and clinical outcomes in children with asthma, 
      suggesting that when pollution exposure is more modest, vulnerability to asthma 
      exacerbations may be heightened in children with higher chronic stress.
FAU - Chen, Edith
AU  - Chen E
AD  - Department of Psychology, University of British Columbia, Vancouver, British 
      Columbia, Canada. echen@psych.ubc.ca
FAU - Schreier, Hannah M C
AU  - Schreier HM
FAU - Strunk, Robert C
AU  - Strunk RC
FAU - Brauer, Michael
AU  - Brauer M
LA  - eng
GR  - R01 HL073975/HL/NHLBI NIH HHS/United States
GR  - HL 073975/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Air Pollutants)
RN  - 0 (Vehicle Emissions)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
CIN - Environ Health Perspect. 2008 Sep;116(9):A376-7; author reply A377. PMID: 
      18795127
MH  - Adolescent
MH  - Air Pollutants/*adverse effects
MH  - Air Pollution/*adverse effects
MH  - Asthma/*etiology/*psychology
MH  - Child
MH  - Environmental Exposure/adverse effects
MH  - Family Relations
MH  - Female
MH  - Humans
MH  - Male
MH  - Nitrogen Dioxide/analysis
MH  - Stress, Psychological/*complications
MH  - Vehicle Emissions/*toxicity
PMC - PMC2453169
OTO - NOTNLM
OT  - air pollution
OT  - asthma
OT  - immune
OT  - psychosocial
OT  - stress
OT  - traffic
EDAT- 2008/07/17 09:00
MHDA- 2008/09/16 09:00
PMCR- 2008/07/01
CRDT- 2008/07/17 09:00
PHST- 2007/11/15 00:00 [received]
PHST- 2008/02/26 00:00 [accepted]
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
PHST- 2008/07/01 00:00 [pmc-release]
AID - ehp0116-000970 [pii]
AID - 10.1289/ehp.11076 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2008 Jul;116(7):970-5. doi: 10.1289/ehp.11076.