PMID- 18629433 OWN - NLM STAT- MEDLINE DCOM- 20081201 LR - 20220331 IS - 0300-9564 (Print) IS - 0300-9564 (Linking) VI - 115 IP - 9 DP - 2008 Sep TI - Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels. PG - 1251-5 LID - 10.1007/s00702-008-0071-2 [doi] AB - This study examined the effects of downhill treadmill exercise on brain-derived neurotrophic factor (BDNF) protein on the hippocampus and striatum of mice. Twenty-four adult mice were assigned to three groups: non-runners control, level or downhill (16 degrees decline) running exercise. The exercise schedule consisted of progressive treadmill running for 5 days week(-1) over 8 weeks. Blood lactate levels classified exercise intensity as moderate to high. Both training types increased citrate synthase activity of the soleus muscle when compared to untrained controls. While level running increased BDNF levels selectively in the hippocampus (68.5%), the eccentric running resulted in a pronounced BDNF increase in both the hippocampus (137.0%) and the striatum (49.9%). Further studies will specify whether the observed alterations in BDNF are due to downhill-induced upregulation or complex learning-induced mechanisms that influence BDNF levels in these brain regions. FAU - Aguiar, Aderbal S Jr AU - Aguiar AS Jr AD - Laboratorio de Fisiologia e Bioquimica do Exercicio, Programa de Pos-Graduacao em Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC 88806-000, Brazil. aderbalaguiar@gmail.com FAU - Speck, Ana E AU - Speck AE FAU - Prediger, Rui D S AU - Prediger RD FAU - Kapczinski, Flavio AU - Kapczinski F FAU - Pinho, Ricardo A AU - Pinho RA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080716 PL - Austria TA - J Neural Transm (Vienna) JT - Journal of neural transmission (Vienna, Austria : 1996) JID - 9702341 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 33X04XA5AT (Lactic Acid) RN - EC 2.3.3.1 (Citrate (si)-Synthase) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Citrate (si)-Synthase/metabolism MH - Corpus Striatum/*metabolism MH - Energy Metabolism/physiology MH - Exercise Test MH - Hippocampus/*metabolism MH - Lactic Acid/blood MH - Learning/physiology MH - Male MH - Mice MH - Muscle, Skeletal/enzymology MH - Physical Conditioning, Animal/*physiology MH - Physical Exertion/*physiology MH - Running/physiology MH - Up-Regulation/*physiology EDAT- 2008/07/17 09:00 MHDA- 2008/12/17 09:00 CRDT- 2008/07/17 09:00 PHST- 2008/03/05 00:00 [received] PHST- 2008/05/14 00:00 [accepted] PHST- 2008/07/17 09:00 [pubmed] PHST- 2008/12/17 09:00 [medline] PHST- 2008/07/17 09:00 [entrez] AID - 10.1007/s00702-008-0071-2 [doi] PST - ppublish SO - J Neural Transm (Vienna). 2008 Sep;115(9):1251-5. doi: 10.1007/s00702-008-0071-2. Epub 2008 Jul 16.