PMID- 18629643
OWN - NLM
STAT- MEDLINE
DCOM- 20090309
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 54
IP  - 2
DP  - 2009 Feb
TI  - Clinical characteristics of patients with hepatitis C virus-related chronic liver 
      disease seropositive for anticentromere antibody.
PG  - 360-8
LID - 10.1007/s10620-008-0359-y [doi]
AB  - The association between anticentromere antibody (ACA) and hepatitis C virus (HCV) 
      infection remains unclear. We subjected eight patients with HCV-related chronic 
      liver disease (CLD) seropositive for ACA to a battery of clinical and laboratory 
      tests. The patient cohort was dominated by females, and four of the eight (50%) 
      patients had a concomitant autoimmune disease. All of the patients had high 
      titers of ACA (>or=1:320). The histological activity index scores in chronic 
      hepatitis C (CH-C) patients with ACA were significantly higher than those in CH-C 
      patients without antinuclear antibody (ANA) (12.8 +/- 1.8 vs. 8.3 +/- 4.5, P = 
      0.0372). The frequency of human leukocyte antigen (HLA) DR-8 in patients with 
      HCV-related CLD seropositive for ACA was significantly higher than that in 
      patients with CH-C seronegative for ANA (71 vs. 18%, P = 0.0108). These findings 
      suggest that ACA is induced by chronic HCV infection in association with HLA 
      DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and 
      inflammation than CH-C patients without ANA.
FAU - Himoto, Takashi
AU  - Himoto T
AD  - Department of Gastroenterology and Neurology, Kagawa University School of 
      Medicine, Kagawa, Japan. thimoto@med.kagawa-u.ac.jp
FAU - Nakai, Seiji
AU  - Nakai S
FAU - Kinekawa, Fumihiko
AU  - Kinekawa F
FAU - Yoneyama, Hirohito
AU  - Yoneyama H
FAU - Deguchi, Akihiro
AU  - Deguchi A
FAU - Kurokochi, Kazutaka
AU  - Kurokochi K
FAU - Masaki, Tsutomu
AU  - Masaki T
FAU - Senda, Shoichi
AU  - Senda S
FAU - Haba, Reiji
AU  - Haba R
FAU - Watanabe, Seishiro
AU  - Watanabe S
FAU - Nishioka, Mikio
AU  - Nishioka M
FAU - Kuriyama, Shigeki
AU  - Kuriyama S
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
DEP - 20080716
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (HLA Antigens)
RN  - 0 (anticentromere antibody)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antinuclear/*blood/*immunology
MH  - Centromere/*immunology
MH  - Female
MH  - HLA Antigens/isolation & purification
MH  - Hepatitis C, Chronic/blood/*immunology/pathology
MH  - Humans
MH  - Liver/pathology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
EDAT- 2008/07/17 09:00
MHDA- 2009/03/10 09:00
CRDT- 2008/07/17 09:00
PHST- 2008/01/06 00:00 [received]
PHST- 2008/06/03 00:00 [accepted]
PHST- 2008/07/17 09:00 [pubmed]
PHST- 2009/03/10 09:00 [medline]
PHST- 2008/07/17 09:00 [entrez]
AID - 10.1007/s10620-008-0359-y [doi]
PST - ppublish
SO  - Dig Dis Sci. 2009 Feb;54(2):360-8. doi: 10.1007/s10620-008-0359-y. Epub 2008 Jul 
      16.