PMID- 18630585
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20161020
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 33
IP  - 2
DP  - 2008 Apr
TI  - [Effect of electroacupuncture pretreatment on glutamate-NMDAR signal pathway in 
      hippocampal neurons of vascular dementia rats].
PG  - 103-6
AB  - OBJECTIVE: To observe the effect of electroacupuncture (EA) pretreatment on 
      hippocampal glutamate (Glu) content and N-methyl-D-aspartate receptor (NMDAR)1 
      mRNA expression in rats with vascular dementia (VD) so as to explore its 
      underlying mechanism in improving VD. METHODS: A total of 72 SD rats were 
      randomized into control (n=16), sham-operation (n=16), model (n=20) and EA 
      pretreatment (n=20) groups. VD model was established by modified middle cerebral 
      artery occlusion. EA (1 mA, 1.7 Hz) was applied to "Baihui" (GV 20), "Shenshu"(BL 
      23) and "Zusanli" (ST 36), once daily for 10 days. Glu content of right 
      hippocampus tissue was detected with chromatometry. NMDAR 1 mRNA expression of 
      hippocampus was detected by in situ hybridization histochemistry. RESULTS: In 
      comparison with sham operation group, Glu content and NMDAR 1 mRNA expression of 
      hippocampus in model group increased significantly (P<0.01). Compared with model 
      group, Glu content and NMDAR 1 mRNA expression of hippocampus in EA pretreatment 
      group decreased significantly (P<0.01, 0.05). CONCLUSION: EA pretreatment can 
      suppress the increase of Glu content, down-regulate NMDAR 1 mRNA expression in VD 
      rats, which may contribute to its effect in relieving VD via reducing apoptosis 
      and protecting cerebral neurons.
FAU - Meng, Pei-Yan
AU  - Meng PY
AD  - Department of Acu-moxibustion and Orthopedics-traumatology, Hubei College of 
      Chinese Medicine, Wuhan 430061, China. meng662006@163.com
FAU - Sun, Guo-Jie
AU  - Sun GJ
FAU - Liu, Sheng-Hong
AU  - Liu SH
FAU - Yan, Hong-Mei
AU  - Yan HM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Dementia, Vascular/metabolism/*therapy
MH  - *Electroacupuncture
MH  - Female
MH  - Glutamic Acid/*analysis
MH  - Hippocampus/*metabolism
MH  - RNA, Messenger/*analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*genetics
MH  - Signal Transduction/*physiology
EDAT- 2008/07/18 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/07/18 09:00
PHST- 2008/07/18 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/07/18 09:00 [entrez]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2008 Apr;33(2):103-6.