PMID- 18630696
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20171116
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 39
IP  - 2
DP  - 2008 Mar
TI  - [The expression of BDNF and PSD-95 in hippocampal CA1 region of 
      morphine-withdrawn rat with different dependent times].
PG  - 253-5
AB  - OBJECTIVE: To observe the expression of brain-derived neurotrophic factor (BDNF) 
      and postsynaptic density-95 (PSD-95) in hippocampal CA1 region of rat with 
      morphine dependence for different times and withdrawn for 1 week, and investigate 
      the influence of that morphine dependence is withdrawn on rat hippocampal CA1 
      area. METHODS: Animal models of rats with morphine withdrawal for 1 week and 
      different morphine dependent times(1 week, 2 weeks, 4 weeks) were established. 
      The expression of BDNF and PSD-95 in hippocampal CA1 were identified with RT-PCR. 
      RESULTS: The expression of BDNF and PSD-95 in hippocampal CA1 decreased in the 
      withdrawn group with morphine dependence for 1 week as compared with that in 
      normal saline (NS) group (P < 0.01), and it increased in the withdrawn group with 
      morphine dependence for 2 weeks as compared with that in morphine-dependent group 
      for 1 week (P < 0.05) but still decreased as compared with that in NS group (P < 
      0.01), and it decreased in the withdrawn group with morphine dependence for 4 
      weeks as compared with the other three groups (P < 0.01). CONCLUSION: The 
      expression of BDNF and PSD-95 in hippocampal CA1 decreases in morphine-depended 
      rats withdrawn for 1 week. Morphine withdrawal has a manifest harm in hippocampal 
      CA1 region of rat.
FAU - Han, Jun-Ge
AU  - Han JG
AD  - Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China.
FAU - Zhu, Hua
AU  - Zhu H
FAU - Chen, Guo-Di
AU  - Chen GD
FAU - Chen, Peng
AU  - Chen P
FAU - Luo, Liang-Ming
AU  - Luo LM
FAU - Liu, Xiao-Ni
AU  - Liu XN
FAU - Wang, Cheng-Bao
AU  - Wang CB
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, rat)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Narcotics)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Disks Large Homolog 4 Protein
MH  - Female
MH  - Gene Expression/drug effects
MH  - Hippocampus/drug effects/*metabolism
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Morphine/administration & dosage/toxicity
MH  - Morphine Dependence/*physiopathology
MH  - Narcotics/administration & dosage/toxicity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Substance Withdrawal Syndrome/*physiopathology
MH  - Time Factors
EDAT- 2008/07/18 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/07/18 09:00
PHST- 2008/07/18 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/07/18 09:00 [entrez]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):253-5.