PMID- 18632089
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20081020
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 64
IP  - 9
DP  - 2008 Nov 1
TI  - Connectivity between posterior parietal cortex and ipsilateral motor cortex is 
      altered in schizophrenia.
PG  - 815-9
LID - 10.1016/j.biopsych.2008.05.026 [doi]
AB  - BACKGROUND: Recent advances have highlighted the hypothesis of schizophrenia as a 
      disorder causing defective connectivity among distinct cortical regions. 
      Neurophysiological evidence supporting this hypothesis, however, is still 
      lacking. METHODS: In the present study, we used a novel twin-coil transcranial 
      magnetic stimulation (tcTMS) approach to investigate ipsilateral parieto-motor 
      connectivity in 20 schizophrenic patients (14 medicated, 6 unmedicated) and in 15 
      healthy age-matched volunteers. RESULTS: In healthy subjects, a conditioning TMS 
      pulse applied over the ipsilateral posterior parietal cortex (PPC) at 90% of 
      resting motor threshold (RMT) intensity was able to increase the excitability of 
      the hand area of the right primary motor cortex, with peaks at interstimulus 
      intervals (ISIs) of 4 and 15 msec. This paradigm of stimulation failed to reveal 
      any facilitatory parieto-motor interaction in medicated and unmedicated 
      schizophrenic patients. The between-group difference in paired-pulse facilitation 
      was not ISI-specific. In following analyses, we found that the effects across 
      ISIs induced by PPC conditioning at 90% RMT correlated with the Global Assessment 
      Functioning score and with the negative subscale of the Positive and Negative 
      Syndrome Scale, showing that patients with a better global functioning and lower 
      negative symptoms had less impaired connectivity. Moreover the same parameter 
      correlated with illness duration. CONCLUSIONS: Parieto-motor connectivity is 
      impaired in schizophrenia. Cortico-cortical disconnection might be a core feature 
      of schizophrenia.
FAU - Koch, Giacomo
AU  - Koch G
AD  - Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, 
      Italy. giakoch@libero.it
FAU - Ribolsi, Michele
AU  - Ribolsi M
FAU - Mori, Francesco
AU  - Mori F
FAU - Sacchetti, Lucia
AU  - Sacchetti L
FAU - Codeca, Claudia
AU  - Codeca C
FAU - Rubino, Ivo Alex
AU  - Rubino IA
FAU - Siracusano, Alberto
AU  - Siracusano A
FAU - Bernardi, Giorgio
AU  - Bernardi G
FAU - Centonze, Diego
AU  - Centonze D
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20080716
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Electric Stimulation/methods
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/pathology/*physiopathology
MH  - Neural Pathways/physiopathology
MH  - Parietal Lobe/pathology/*physiopathology
MH  - Schizophrenia/*pathology
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
EDAT- 2008/07/18 09:00
MHDA- 2009/04/09 09:00
CRDT- 2008/07/18 09:00
PHST- 2008/02/11 00:00 [received]
PHST- 2008/05/29 00:00 [revised]
PHST- 2008/05/31 00:00 [accepted]
PHST- 2008/07/18 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2008/07/18 09:00 [entrez]
AID - S0006-3223(08)00690-2 [pii]
AID - 10.1016/j.biopsych.2008.05.026 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2008 Nov 1;64(9):815-9. doi: 10.1016/j.biopsych.2008.05.026. 
      Epub 2008 Jul 16.