PMID- 18633846 OWN - NLM STAT- MEDLINE DCOM- 20081210 LR - 20091211 IS - 1747-0927 (Electronic) IS - 1747-0919 (Linking) VI - 3 IP - 1 DP - 2008 TI - Observing social interactions: the effect of gaze. PG - 51-9 LID - 10.1080/17470910701563269 [doi] AB - Our social abilities depend on specialized brain systems that allow us to perform crucial operations such as interpreting the actions of others. This functional magnetic resonance imaging (fMRI) study investigated whether human brain activity evoked by the observation of social interactions is modulated by gaze. During scanning participants observed social or individual actions performed by agents whose gaze could be either available or masked. Results demonstrated that the observation of social interactions evoked activity within a dorsal sector of the medial prefrontal cortex (MPFC), an area classically involved in social cognition. Importantly, activity within this area was modulated by whether the gaze of the agents performing the observed action was or was not available. The implications of these findings for a role played by the dorsal medial prefrontal cortex (dMPFC) in terms of inferential processes concerned with social interactions are considered. FAU - Pierno, Andrea C AU - Pierno AC AD - University of Padova, Padova, Italy. FAU - Becchio, Cristina AU - Becchio C FAU - Turella, Luca AU - Turella L FAU - Tubaldi, Federico AU - Tubaldi F FAU - Castiello, Umberto AU - Castiello U LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Soc Neurosci JT - Social neuroscience JID - 101279009 SB - IM MH - Adolescent MH - Adult MH - Brain/physiology MH - Brain Mapping/methods MH - Female MH - Fixation, Ocular/*physiology MH - Humans MH - *Interpersonal Relations MH - Male MH - Photic Stimulation/methods EDAT- 2008/07/18 09:00 MHDA- 2008/12/17 09:00 CRDT- 2008/07/18 09:00 PHST- 2008/07/18 09:00 [pubmed] PHST- 2008/12/17 09:00 [medline] PHST- 2008/07/18 09:00 [entrez] AID - 781530808 [pii] AID - 10.1080/17470910701563269 [doi] PST - ppublish SO - Soc Neurosci. 2008;3(1):51-9. doi: 10.1080/17470910701563269.