PMID- 18634420
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20180222
IS  - 0029-0831 (Print)
IS  - 0029-0831 (Linking)
VI  - 40
IP  - 4
DP  - 2008 Jul
TI  - [A 5-year-old boy with nonconvulsive status epilepticus induced by theophylline 
      treatment].
PG  - 328-32
AB  - A normally developed 5-year-old boy with no history of convulsive disorder 
      presented with a generalized tonic-clonic convulsion on the second day of oral 
      theophylline therapy. Although the convulsive seizure was abolished by an 
      intravenous bolus of diazepam, he did not regain consciousness. Emergency 
      electroencephalography disclosed continuous irregular seizure activity, occurring 
      predominantly over the right hemisphere, indicating a diagnosis of nonconvulsive 
      status epilepticus (NCSE). The serum theophylline concentration was 19.7 
      microg/mL. Treatment with an initial intravenous bolus of midazolam (0.26 mg/kg) 
      largely restricted seizure activity to the right hemisphere, with activity then 
      diminishing to continuous right occipital spikes. An additional 0.24 mg/kg bolus 
      followed by continuous infusion at a rate of 0.20 mg/kg/hr completely abolished 
      electrical status. Our case suggests that theophylline treatment can provoke NCSE 
      even after successful control of a brief convulsion by initial antiseizure 
      treatment in some patients predisposed toward localization-related epilepsy. This 
      possibility should be kept in mind in any child receiving theophylline who 
      presents with sustained unconsciousness.
FAU - Nobutoki, Tatsuro
AU  - Nobutoki T
AD  - Department of Pediatrics, National Mie Hospital, Tsu, Mie. 
      nbtk.yokohama.ped@biscuit.ocn.ne.jp
FAU - Takahashi, Jyun-ya
AU  - Takahashi JY
FAU - Ihara, Toshiaki
AU  - Ihara T
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - No To Hattatsu
JT  - No to hattatsu = Brain and development
JID - 0215224
RN  - C137DTR5RG (Theophylline)
SB  - IM
MH  - Administration, Oral
MH  - Child, Preschool
MH  - Humans
MH  - Male
MH  - Status Epilepticus/*chemically induced
MH  - Theophylline/administration & dosage/*adverse effects
EDAT- 2008/07/19 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/07/19 09:00
PHST- 2008/07/19 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/07/19 09:00 [entrez]
PST - ppublish
SO  - No To Hattatsu. 2008 Jul;40(4):328-32.