PMID- 18634819
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20211020
IS  - 0047-6374 (Print)
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 129
IP  - 10
DP  - 2008 Oct
TI  - Genes regulated by caloric restriction have unique roles within transcriptional 
      networks.
PG  - 580-92
LID - 10.1016/j.mad.2008.06.001 [doi]
AB  - Caloric restriction (CR) has received much interest as an intervention that 
      delays age-related disease and increases lifespan. Whole-genome microarrays have 
      been used to identify specific genes underlying these effects, and in mice, this 
      has led to the identification of genes with expression responses to CR that are 
      shared across multiple tissue types. Such CR-regulated genes represent strong 
      candidates for future investigation, but have been understood only as a list, 
      without regard to their broader role within transcriptional networks. In this 
      study, co-expression and network properties of CR-regulated genes were 
      investigated using data generated by more than 600 Affymetrix microarrays. This 
      analysis identified groups of co-expressed genes and regulatory factors 
      associated with the mammalian CR response, and uncovered surprising network 
      properties of CR-regulated genes. Genes downregulated by CR were highly connected 
      and located in dense network regions. In contrast, CR-upregulated genes were 
      weakly connected and positioned in sparse network regions. Some network 
      properties were mirrored by CR-regulated genes from invertebrate models, 
      suggesting an evolutionary basis for the observed patterns. These findings 
      contribute to a systems-level picture of how CR influences transcription within 
      mammalian cells, and point towards a comprehensive understanding of CR in terms 
      of its influence on biological networks.
FAU - Swindell, William R
AU  - Swindell WR
AD  - Department of Pathology, University of Michigan, Ann Arbor, MI 48109-2200, USA. 
      wswindel@umich.edu
LA  - eng
GR  - T32 AG000114/AG/NIA NIH HHS/United States
GR  - T32 AG000114-24/AG/NIA NIH HHS/United States
GR  - Z01 AG000114/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080627
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans
MH  - *Caloric Restriction
MH  - Drosophila
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - *Gene Regulatory Networks
MH  - Mice
MH  - Models, Biological
MH  - Models, Genetic
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Transcription, Genetic
PMC - PMC2688445
MID - NIHMS110370
EDAT- 2008/07/19 09:00
MHDA- 2009/02/03 09:00
PMCR- 2009/05/29
CRDT- 2008/07/19 09:00
PHST- 2008/03/12 00:00 [received]
PHST- 2008/06/09 00:00 [revised]
PHST- 2008/06/15 00:00 [accepted]
PHST- 2008/07/19 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PHST- 2008/07/19 09:00 [entrez]
PHST- 2009/05/29 00:00 [pmc-release]
AID - S0047-6374(08)00143-7 [pii]
AID - 10.1016/j.mad.2008.06.001 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2008 Oct;129(10):580-92. doi: 10.1016/j.mad.2008.06.001. Epub 
      2008 Jun 27.