PMID- 18635557
OWN - NLM
STAT- MEDLINE
DCOM- 20090324
LR  - 20240417
IS  - 1464-3553 (Electronic)
IS  - 0379-864X (Print)
IS  - 0379-864X (Linking)
VI  - 33
IP  - 8
DP  - 2008 Oct
TI  - Greater superficial petrosal nerve transection in rats does not change 
      unconditioned licking responses to putatively sweet taste stimuli.
PG  - 709-23
LID - 10.1093/chemse/bjn039 [doi]
AB  - The greater superficial petrosal nerve (GSP), innervating taste buds in the 
      palate, is known to be exceptionally responsive to sucrose, especially compared 
      with the responsiveness of the chorda tympani nerve (CT). However, whereas 
      transection of the CT (CTX) alone has little or no effect on unconditioned 
      licking responses to many "sweet" stimuli, the impact of GSP transection (GSPX) 
      alone is equivocal. To further examine the role of the GSP on licking responses 
      to putatively sweet-tasting substances, brief-access taste tests were conducted 
      in nondeprived rats before and after sham surgery (SHAM) or CTX or GSPX. A range 
      of concentrations of sucrose, L-alanine, glycine, and L-serine, with and without 
      1.0 mM inosine monophosphate (IMP) added, were used. All groups showed 
      significant concentration-dependent increases in licking to all stimuli 
      presurgically and postsurgically. CTX decreased licking responses relative to 
      SHAM rats in the first sucrose test. There was also a group x concentration 
      interaction for L-alanine, but post hoc tests did not reveal its basis. Other 
      than this, there were no significant differences among the surgical groups. 
      Interestingly, rats with GSPX tended to initiate fewer trials than SHAM rats. 
      Overall, after GSPX, the remaining gustatory nerves are apparently sufficient to 
      maintain concentration-dependent licking responses to all stimuli tested here. 
      The disparity between our results and others in the literature where GSPX reduced 
      licking responses to sucrose is possibly related to differences in surgical 
      technique or test trial duration.
FAU - Jiang, Enshe
AU  - Jiang E
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, FL 32306, USA.
FAU - Blonde, Ginger
AU  - Blonde G
FAU - Garcea, Mircea
AU  - Garcea M
FAU - Spector, Alan C
AU  - Spector AC
LA  - eng
GR  - R01-DC01628/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080716
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Conditioning, Psychological
MH  - Electrophysiology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stimulation, Chemical
MH  - Sucrose/*pharmacology
MH  - Taste/drug effects/*physiology
MH  - Tongue/*drug effects/*innervation/physiology/surgery
PMC - PMC2720699
EDAT- 2008/07/19 09:00
MHDA- 2009/03/25 09:00
PMCR- 2009/10/01
CRDT- 2008/07/19 09:00
PHST- 2008/07/19 09:00 [pubmed]
PHST- 2009/03/25 09:00 [medline]
PHST- 2008/07/19 09:00 [entrez]
PHST- 2009/10/01 00:00 [pmc-release]
AID - bjn039 [pii]
AID - 10.1093/chemse/bjn039 [doi]
PST - ppublish
SO  - Chem Senses. 2008 Oct;33(8):709-23. doi: 10.1093/chemse/bjn039. Epub 2008 Jul 16.