PMID- 18635873
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20211020
IS  - 8750-7587 (Print)
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 105
IP  - 3
DP  - 2008 Sep
TI  - TNF promoter polymorphisms associated with muscle phenotypes in humans.
PG  - 859-67
LID - 10.1152/japplphysiol.90655.2008 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent catabolic factor to skeletal 
      muscle. Single-nucleotide polymorphisms (SNPs) in the promoter region of the 
      TNF-alpha coding gene, TNF, have been implicated in the interindividual variation 
      in TNF-alpha production via transcriptional regulation. The present study 
      investigated the association of muscle phenotypes with five TNF promoter SNPs, 
      which potentially have biological significance. Female and male volunteers (n = 
      1,050) from the Baltimore Longitudinal Study of Aging were genotyped, and their 
      regional and total body muscle mass, and arm and leg muscle strength were 
      measured. Results indicated that putative high-expression alleles at positions 
      -1031 and -863, individually or in combination in the haplotype 
      1031C-863A-857C-308G-238G, were associated with lower muscle mass in men. 
      Specifically, carriers of -1031C, compared with noncarriers, exhibited lower arm 
      muscle mass (6.4 +/- 0.1 vs. 6.8 +/- 0.1 kg, P = 0.01) and appendicular skeletal 
      muscle mass (ASM) (24.3 +/- 0.4 vs. 25.4 +/- 0.2 kg, P = 0.02), with leg muscle 
      mass and the ASM index (ASMI; kg/m(2)) also tending to be lower (P = 0.06 and 
      0.07). Similarly, -863A allele carriers (linked with -1031), compared with 
      noncarriers, exhibited lower arm muscle mass (6.4 +/- 0.1 vs. 6.8 +/- 0.1 kg, P = 
      0.04). Carriers of the haplotype 1031C-863A-857C-308G-238G, compared with 
      noncarriers, exhibited lower arm muscle mass (6.3 +/- 0.2 vs. 6.8 +/- 0.1 kg, P < 
      0.01), trunk muscle mass (25.7 +/- 0.5 vs. 26.9 +/- 0.3 kg, P < 0.05), and ASM 
      (24.1 +/- 0.5 vs. 25.3 +/- 0.2 kg, P < 0.025), with tendencies for lower leg 
      muscle mass and ASMI (P = 0.07 and 0.08). Results indicate that genetic variation 
      in the TNF locus may contribute to the interindividual variation in muscle 
      phenotypes in men.
FAU - Liu, Dongmei
AU  - Liu D
AD  - Dept. of Kinesiology, Univ. of Maryland, College Park, MD 20742-2611, USA.
FAU - Metter, E Jeffrey
AU  - Metter EJ
FAU - Ferrucci, Luigi
AU  - Ferrucci L
FAU - Roth, Stephen M
AU  - Roth SM
LA  - eng
GR  - L30 AG024705-02/AG/NIA NIH HHS/United States
GR  - K01 AG022791-02/AG/NIA NIH HHS/United States
GR  - K01 AG022791-04/AG/NIA NIH HHS/United States
GR  - R01 AG021500-01A1/AG/NIA NIH HHS/United States
GR  - K01 AG022791-01/AG/NIA NIH HHS/United States
GR  - K01 AG022791-05/AG/NIA NIH HHS/United States
GR  - K01 AG022791/AG/NIA NIH HHS/United States
GR  - R01 AG021500/AG/NIA NIH HHS/United States
GR  - L30 AG024705/AG/NIA NIH HHS/United States
GR  - AG-022791/AG/NIA NIH HHS/United States
GR  - R01 AG021500-03/AG/NIA NIH HHS/United States
GR  - AG-021500/AG/NIA NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - K01 AG022791-03/AG/NIA NIH HHS/United States
GR  - R01 AG021500-02/AG/NIA NIH HHS/United States
GR  - L30 AG024705-03/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20080717
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Arm
MH  - Baltimore
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Leg
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - *Muscle, Skeletal/pathology/physiopathology
MH  - Muscular Diseases/*genetics/pathology/physiopathology
MH  - Organ Size
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Sex Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC2536817
EDAT- 2008/07/19 09:00
MHDA- 2008/10/04 09:00
PMCR- 2009/09/01
CRDT- 2008/07/19 09:00
PHST- 2008/07/19 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/07/19 09:00 [entrez]
PHST- 2009/09/01 00:00 [pmc-release]
AID - 90655.2008 [pii]
AID - JAPPL-90655-2008 [pii]
AID - 10.1152/japplphysiol.90655.2008 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2008 Sep;105(3):859-67. doi: 
      10.1152/japplphysiol.90655.2008. Epub 2008 Jul 17.