PMID- 18637012
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20211020
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 19
IP  - 3
DP  - 2009 Jul
TI  - Monocyte chemoattractant protein-1 plays a dominant role in the chronic 
      inflammation observed in Alzheimer's disease.
PG  - 392-8
LID - 10.1111/j.1750-3639.2008.00188.x [doi]
AB  - Chronic neuroinflammation correlates with cognitive decline and brain atrophy in 
      Alzheimer's disease (AD), and cytokines and chemokines mediate the inflammatory 
      response. However, quantitation of cytokines and chemokines in AD brain tissue 
      has only been carried out for a small number of mediators with variable results. 
      We simultaneously quantified 17 cytokines and chemokines in brain tissue extracts 
      from controls (n = 10) and from patients with and without genetic forms of AD (n 
      = 12). Group comparisons accounting for multiple testing revealed that monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) 
      were consistently upregulated in AD brain tissue. Immunohistochemistry for MCP-1, 
      IL-6 and IL-8 confirmed this increase and determined localization of these 
      factors in neurons (MCP-1, IL-6, IL-8), astrocytes (MCP-1, IL-6) and plaque 
      pathology (MCP-1, IL-8). Logistic linear regression modeling determined that 
      MCP-1 was the most reliable predictor of disease. Our data support previous work 
      on significant increases in IL-6 and IL-8 in AD but indicate that MCP-1 may play 
      a more dominant role in chronic inflammation in AD.
FAU - Sokolova, Anna
AU  - Sokolova A
AD  - Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, 
      Australia.
FAU - Hill, Michelle D
AU  - Hill MD
FAU - Rahimi, Farid
AU  - Rahimi F
FAU - Warden, Lolita A
AU  - Warden LA
FAU - Halliday, Glenda M
AU  - Halliday GM
FAU - Shepherd, Claire E
AU  - Shepherd CE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080710
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/metabolism/*pathology
MH  - Astrocytes/metabolism/pathology
MH  - Brain/metabolism/*pathology
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation/metabolism/*pathology
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neurons/metabolism/pathology
MH  - Plaque, Amyloid/metabolism/pathology
PMC - PMC8094842
EDAT- 2008/07/19 09:00
MHDA- 2009/10/02 06:00
PMCR- 2008/07/10
CRDT- 2008/07/19 09:00
PHST- 2008/07/19 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
PHST- 2008/07/19 09:00 [entrez]
PHST- 2008/07/10 00:00 [pmc-release]
AID - BPA188 [pii]
AID - 10.1111/j.1750-3639.2008.00188.x [doi]
PST - ppublish
SO  - Brain Pathol. 2009 Jul;19(3):392-8. doi: 10.1111/j.1750-3639.2008.00188.x. Epub 
      2008 Jul 10.