PMID- 18637823
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 15
IP  - 9
DP  - 2008 Sep
TI  - Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in 
      an immunocompetent adult population.
PG  - 995-7
LID - 10.1111/j.1468-1331.2008.02233.x [doi]
AB  - BACKGROUND AND AIM: Human herpesviruses (HHVs) and enteroviruses (EVs) are the 
      major causative agents of CNS viral infections. The aim of the study was to 
      identify the etiology and determine the frequency of aseptic meningitis and 
      encephalitis due to HHVs and EVs in an immunocompetent adult population. METHODS: 
      Eighty-one patients (ages >or=15) with aseptic meningitis or encephalitis treated 
      in the Infectious Diseases Hospital of Thessaloniki, Greece, during 2003-2006, 
      were included in the study. Polymerase chain reaction for detection of herpes- 
      and enterovirus genome direct in cerebrospinal fluid samples was performed. 
      RESULTS: Based on clinical and laboratory data, 36/81 patients had meningitis and 
      45/81 had encephalitis. Etiology was defined in 11 patients (31%) with aseptic 
      meningitis. EVs were the major causative agents (8/36, 22%), followed by 
      varicella zoster virus (2/36, 5%) and herpes simplex virus-2 (HSV-2) (1/36, 3%). 
      Etiology was identified in 8 of 45 (18%) patients with encephalitis, EV (4/45, 
      9%) and HSV-1 (4/45, 9%) being the most common pathogens. CONCLUSION: 
      Enteroviruses are the most common cause of adult aseptic meningitis and together 
      with HSV-1 the main causes of encephalitis.
FAU - Frantzidou, F
AU  - Frantzidou F
AD  - A Department of Microbiology, School of Medicine, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece. filanthi@med.auth.gr
FAU - Kamaria, F
AU  - Kamaria F
FAU - Dumaidi, K
AU  - Dumaidi K
FAU - Skoura, L
AU  - Skoura L
FAU - Antoniadis, A
AU  - Antoniadis A
FAU - Papa, A
AU  - Papa A
LA  - eng
PT  - Journal Article
DEP - 20080714
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - DNA, Viral/cerebrospinal fluid
MH  - Encephalitis, Herpes Simplex/cerebrospinal fluid/epidemiology/virology
MH  - Encephalitis, Viral/cerebrospinal fluid/*epidemiology/virology
MH  - Enterovirus/isolation & purification
MH  - Enterovirus Infections/cerebrospinal fluid/*epidemiology
MH  - Female
MH  - Greece/epidemiology
MH  - Herpesviridae Infections/cerebrospinal fluid/*epidemiology
MH  - Herpesvirus 1, Human/isolation & purification
MH  - Herpesvirus 2, Human/isolation & purification
MH  - Humans
MH  - Immunocompetence
MH  - Male
MH  - Meningitis, Aseptic/cerebrospinal fluid/*epidemiology/virology
MH  - Middle Aged
MH  - RNA, Viral/cerebrospinal fluid
EDAT- 2008/07/22 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/07/22 09:00
PHST- 2008/07/22 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/07/22 09:00 [entrez]
AID - ENE2233 [pii]
AID - 10.1111/j.1468-1331.2008.02233.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2008 Sep;15(9):995-7. doi: 10.1111/j.1468-1331.2008.02233.x. Epub 
      2008 Jul 14.