PMID- 18637869
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20090303
LR  - 20081021
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 53
IP  - 5
DP  - 2008 Sep
TI  - N-cyanomethyl-N-methyl-1-(3',4'-methylenedioxyphenyl)-2-propylamine: an MDMA 
      manufacturing by-product.
PG  - 1083-91
LID - 10.1111/j.1556-4029.2008.00817.x [doi]
AB  - This paper describes the structural elucidation of a compound produced during the 
      synthesis of 3,4-methylenedioxymethylamphetamine (MDMA) via the reductive 
      amination of 3,4-methylenedioxyphenyl-2-propanone (3,4-MDP-2-P) with methylamine 
      and sodium cyanoborohydride. The compound was isolated from MDMA by column 
      chromatography, proton and carbon nuclear magnetic resonance spectroscopy, 
      LC/mass spectrometry, and total synthesis were used to identify the compound as 
      N-cyanomethyl-N-methyl-1-(3',4'-methylenedioxyphenyl)-2-propylamine. This 
      compound has been identified as a potential synthetic route marker for the 
      reductive amination of 3,4-MDP-2-P with methylamine and sodium cyanoborohydride 
      and as such it should prove valuable to forensic scientists engaged in profiling 
      illicit drugs. Profiling MDMA can provide useful information to law enforcement 
      agencies relating to synthetic route, precursor chemicals and reagents employed 
      and may be used for comparative analyses of different drug seizures. This paper 
      also describes the structural elucidation of the analogous methylamphetamine 
      synthetic route marker compound, N-cyanomethyl-N-methyl-1-phenyl-2-propylamine, 
      produced during the reductive amination of phenyl-2-propanone using methylamine 
      and sodium cyanoborohydride.
FAU - Salouros, Helen
AU  - Salouros H
AD  - National Measurement Institute, 1 Suakin St, Pymble, NSW, Australia.
FAU - Collins, Michael
AU  - Collins M
FAU - Tarrant, Gregory
AU  - Tarrant G
FAU - George, Adrian V
AU  - George AV
LA  - eng
PT  - Journal Article
DEP - 20080714
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
EDAT- 2008/07/22 09:00
MHDA- 2008/07/22 09:01
CRDT- 2008/07/22 09:00
PHST- 2008/07/22 09:00 [pubmed]
PHST- 2008/07/22 09:01 [medline]
PHST- 2008/07/22 09:00 [entrez]
AID - JFO817 [pii]
AID - 10.1111/j.1556-4029.2008.00817.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2008 Sep;53(5):1083-91. doi: 10.1111/j.1556-4029.2008.00817.x. 
      Epub 2008 Jul 14.