PMID- 18639521
OWN - NLM
STAT- MEDLINE
DCOM- 20080905
LR  - 20240315
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 374
IP  - 3
DP  - 2008 Sep 26
TI  - Curcumin prevents human dendritic cell response to immune stimulants.
PG  - 431-6
LID - 10.1016/j.bbrc.2008.07.051 [doi]
AB  - Curcumin, a compound found in the Indian spice turmeric, has anti-inflammatory 
      and immunomodulatory properties, though the mechanism remains unclear. Dendritic 
      cells (DCs) are important to generating an immune response and the effect of 
      curcumin on human DCs has not been explored. The role curcumin in the DC response 
      to bacterial and viral infection was investigated in vitro using LPS and Poly I:C 
      as models of infection. CD14(+) monocytes, isolated from human peripheral blood, 
      were cultured in GM-CSF- and IL-4-supplemented medium to generate immature DCs. 
      Cultures were incubated with curcumin, stimulated with LPS or Poly I:C and 
      functional assays were performed. Curcumin prevents DCs from responding to 
      immunostimulants and inducing CD4(+) T cell proliferation by blocking maturation 
      marker, cytokine and chemokine expression and reducing both migration and 
      endocytosis. These data suggest a therapeutic role for curcumin as an immune 
      suppressant.
FAU - Shirley, Shawna A
AU  - Shirley SA
AD  - Department of Molecular Medicine, College of Medicine, University of South 
      Florida, Tampa, FL 33612, USA.
FAU - Montpetit, Alison J
AU  - Montpetit AJ
FAU - Lockey, R F
AU  - Lockey RF
FAU - Mohapatra, Shyam S
AU  - Mohapatra SS
LA  - eng
GR  - P30 HL101265/HL/NHLBI NIH HHS/United States
GR  - P30 HL101265-02/HL/NHLBI NIH HHS/United States
GR  - R01 CA152005/CA/NCI NIH HHS/United States
GR  - R01 CA152005-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080717
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Lipopolysaccharides)
RN  - IT942ZTH98 (Curcumin)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Adjuvants, Immunologic/*antagonists & inhibitors/pharmacology
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Biomarkers/metabolism
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Adhesion Molecules/antagonists & inhibitors/metabolism
MH  - Cell Movement/drug effects
MH  - Chemokines/metabolism
MH  - Curcumin/*pharmacology
MH  - Dendritic Cells/*drug effects/immunology
MH  - Endocytosis/drug effects
MH  - Humans
MH  - Immunosuppressive Agents/*pharmacology
MH  - Lipopolysaccharides/antagonists & inhibitors/immunology
MH  - Lymphocyte Activation/drug effects
MH  - Lymphocyte Culture Test, Mixed
MH  - Poly I-C/antagonists & inhibitors/immunology
PMC - PMC3319308
MID - NIHMS66522
EDAT- 2008/07/22 09:00
MHDA- 2008/09/06 09:00
PMCR- 2012/04/04
CRDT- 2008/07/22 09:00
PHST- 2008/07/02 00:00 [received]
PHST- 2008/07/03 00:00 [accepted]
PHST- 2008/07/22 09:00 [pubmed]
PHST- 2008/09/06 09:00 [medline]
PHST- 2008/07/22 09:00 [entrez]
PHST- 2012/04/04 00:00 [pmc-release]
AID - S0006-291X(08)01323-5 [pii]
AID - 10.1016/j.bbrc.2008.07.051 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2008 Sep 26;374(3):431-6. doi: 
      10.1016/j.bbrc.2008.07.051. Epub 2008 Jul 17.