PMID- 18641249
OWN - NLM
STAT- MEDLINE
DCOM- 20080812
LR  - 20080721
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 248
IP  - 2
DP  - 2008 Aug
TI  - Isovolumic cardiac contraction on high-temporal-resolution cine MR images: study 
      in heart failure patients and healthy volunteers.
PG  - 458-65
LID - 10.1148/radiol.2482071103 [doi]
AB  - PURPOSE: To prospectively implement high-temporal-resolution cine magnetic 
      resonance (MR) imaging protocol to compare cardiac preejection contraction (PEC) 
      and prefilling relaxation (PFR) times between heart failure (HF) patients and 
      healthy control subjects and to assess accuracy of PEC times to stratify HF 
      patients, with ejection fraction (EF) and New York Heart Association (NYHA) 
      symptom class as reference standards. MATERIALS AND METHODS: Following 
      institutional review board approval of this HIPAA-compliant study and written 
      informed consent, 18 healthy volunteers (10 women, eight men; mean age, 43 years 
      +/- 14 [standard deviation]) and 18 HF patients (five women, 13 men; mean age, 
      49.8 years +/- 3) were imaged (breath-hold true fast imaging with steady-state 
      precession, with temporal resolution of 5.6 msec at 1.5 T). By using left 
      ventricular (LV) outflow tract acquisition, PEC phase was defined as time at QRS 
      trigger to immediately before aortic valve opening. PFR was defined as time from 
      initial aortic valve closure to immediately before mitral valve opening. Group 
      means were compared (unpaired Student t test). Accuracy of PEC parameters in 
      stratifying participants with severe systolic HF on the basis of EF and NYHA 
      symptom class was assessed (receiver operating characteristic curve analysis). 
      RESULTS: Compared with control subjects, HF patients had prolonged mean PEC time 
      (40.4 msec +/- 11.8 vs 91.3 msec +/- 26, P < .001) and mean PFR time (68.3 msec 
      +/- 26.8 vs 103.7 msec +/- 41.8, P < .01). PEC time correlated with global EF (r 
      = -0.73, P < .001) and LV mass (r = 0.69, P < .001). For identification of 
      patients with severe LV systolic dysfunction (EF <or= 35%), PEC time was highly 
      accurate (area under the curve [AUC], 0.900 [P < .001]). For identification of 
      patients with moderate-to-severe HF symptoms (NYHA class > 2), PEC time had good 
      accuracy (AUC, 0.875 [P < .001]). CONCLUSION: It is feasible to assess isovolumic 
      PEC and PFR phases of the cardiac cycle with high-frame-rate cine MR images, and 
      PEC time is a surrogate measure of moderate-to-severe systolic HF.
FAU - Dinh, Howard V
AU  - Dinh HV
AD  - Department of Medicine, Division of Cardiology, David Geffen School of Medicine 
      at UCLA, 10945 Leconte Ave, Peter Ueberroth Blvd, Room 3371D, Los Angeles, CA 
      90025, USA. hdinh@post.harvard.edu
FAU - Alvergue, Juan
AU  - Alvergue J
FAU - Sayre, James
AU  - Sayre J
FAU - Child, John S
AU  - Child JS
FAU - Deshpande, Vibhas S
AU  - Deshpande VS
FAU - Laub, Gerhard
AU  - Laub G
FAU - Finn, J Paul
AU  - Finn JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Heart Function Tests
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Prospective Studies
MH  - ROC Curve
EDAT- 2008/07/22 09:00
MHDA- 2008/08/13 09:00
CRDT- 2008/07/22 09:00
PHST- 2008/07/22 09:00 [pubmed]
PHST- 2008/08/13 09:00 [medline]
PHST- 2008/07/22 09:00 [entrez]
AID - 248/2/458 [pii]
AID - 10.1148/radiol.2482071103 [doi]
PST - ppublish
SO  - Radiology. 2008 Aug;248(2):458-65. doi: 10.1148/radiol.2482071103.