PMID- 18642023
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20211020
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 246
IP  - 10
DP  - 2008 Oct
TI  - Natural course of experimental retinal vein occlusion in rabbit; arterial 
      occlusion following venous photothrombosis.
PG  - 1429-39
LID - 10.1007/s00417-008-0878-4 [doi]
AB  - BACKGROUND: Retinal vein occlusion (RVO) is the second leading cause of vascular 
      eye disease. Currently there is no definite treatment for this condition. Animal 
      models could be potentially helpful in developing new treatments; however, it is 
      essential to understand the differences these models may have with human RVO. The 
      aim of our study was to examine the course of experimentally created retinal vein 
      occlusion (RVO) in rabbits. METHODS: Twenty-nine pigmented rabbits were included 
      in the study. RVO was created in all using an argon green laser following 
      intravenous injection of Rose Bengal. A laser was applied to all major veins at 
      the optic disc margin to mimic central retinal vein occlusion. Animals were 
      followed-up for a maximum of 2 months. RESULTS: Immediately following laser 
      application, blood flow ceased or the flow was extremely slow in the retinal 
      veins in all cases. At day 2 post laser, 86% showed significant retinal 
      hemorrhages. On FA, no retinal blood flow was observed in the eye (neither 
      arteries nor veins) in the majority of rabbits. Between weeks 1 and 3, laser 
      sites reopened and partial or complete revascularization of both retinal arteries 
      and veins occurred; however, the vascular pattern was abnormal. CONCLUSIONS: RVO 
      in rabbits has a different course than in human and it can be classified into 
      three stages. At stage 1 (the first few days after laser photothrombosis), there 
      is a retrograde propagation of the blood clot in the retinal veins that extends 
      to the retinal arteries and choriocapillaries. As a result, there is no retinal 
      blood flow at this stage in most cases. At stage 2 (between weeks 1 and 3), 
      partial or complete revascularization occurs but the vessels have an abnormal 
      pattern. At stage 3 (after week 3) no significant change takes place.
FAU - Ameri, Hossein
AU  - Ameri H
AD  - Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, 
      University of Southern California, Los Angeles, CA, USA. hameri@doheny.org
FAU - Ratanapakorn, Tanapat
AU  - Ratanapakorn T
FAU - Rao, Narsing A
AU  - Rao NA
FAU - Chader, Gerald J
AU  - Chader GJ
FAU - Humayun, Mark S
AU  - Humayun MS
LA  - eng
PT  - Journal Article
DEP - 20080719
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Coloring Agents)
RN  - 1ZPG1ELY14 (Rose Bengal)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Animals
MH  - Coloring Agents/administration & dosage
MH  - Disease Models, Animal
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Indocyanine Green
MH  - Injections, Intravenous
MH  - Intraocular Pressure
MH  - *Laser Coagulation
MH  - Lasers, Gas
MH  - Photography
MH  - Rabbits
MH  - Regional Blood Flow
MH  - Retinal Artery Occlusion/diagnosis/etiology/*physiopathology
MH  - Retinal Hemorrhage/diagnosis/etiology/*physiopathology
MH  - Retinal Vein/*physiopathology/surgery
MH  - Retinal Vein Occlusion/diagnosis/etiology/*physiopathology
MH  - Rose Bengal/administration & dosage
MH  - Time Factors
MH  - Tomography, Optical Coherence
EDAT- 2008/07/22 09:00
MHDA- 2009/01/27 09:00
CRDT- 2008/07/22 09:00
PHST- 2008/03/18 00:00 [received]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/05/23 00:00 [revised]
PHST- 2008/07/22 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2008/07/22 09:00 [entrez]
AID - 10.1007/s00417-008-0878-4 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2008 Oct;246(10):1429-39. doi: 
      10.1007/s00417-008-0878-4. Epub 2008 Jul 19.