PMID- 18643961
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 72
IP  - 4
DP  - 2008 Oct
TI  - A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a 
      Caucasoid Brazilian population with psoriasis vulgaris.
PG  - 392-6
LID - 10.1111/j.1399-0039.2008.01096.x [doi]
AB  - Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic 
      background remain unclear. Considering that previous studies have suggested an 
      association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like 
      receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 
      79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase 
      chain reaction (PCR) using sequence-specific oligonucleotides and 
      sequence-specific primers. We did not observe a relevant increase in the 
      frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases 
      (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with 
      Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% 
      of controls. These results suggest that activating KIR2DS1 gene may not confer 
      susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ 
      was observed in these patients.
FAU - Jobim, M
AU  - Jobim M
AD  - Department of Immunology, Hospital de Clinicas, Porto Alegre, Brazil. 
      mjobim@hcpa.ufrgs.br
FAU - Jobim, L F J
AU  - Jobim LF
FAU - Salim, P H
AU  - Salim PH
FAU - Cestari, T F
AU  - Cestari TF
FAU - Toresan, R
AU  - Toresan R
FAU - Gil, B C
AU  - Gil BC
FAU - Jobim, M R
AU  - Jobim MR
FAU - Wilson, T J
AU  - Wilson TJ
FAU - Kruger, M
AU  - Kruger M
FAU - Schlottfeldt, J
AU  - Schlottfeldt J
FAU - Schwartsmann, G
AU  - Schwartsmann G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080715
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06:02 antigen)
RN  - 0 (KIR2DS1 protein, human)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - Brazil/epidemiology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Psoriasis/epidemiology/*genetics
MH  - Receptors, KIR/*genetics
EDAT- 2008/07/23 09:00
MHDA- 2009/05/19 09:00
CRDT- 2008/07/23 09:00
PHST- 2008/07/23 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
PHST- 2008/07/23 09:00 [entrez]
AID - TAN1096 [pii]
AID - 10.1111/j.1399-0039.2008.01096.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Oct;72(4):392-6. doi: 10.1111/j.1399-0039.2008.01096.x. 
      Epub 2008 Jul 15.