PMID- 18644671
OWN - NLM
STAT- MEDLINE
DCOM- 20090407
LR  - 20121115
IS  - 0304-3894 (Print)
IS  - 0304-3894 (Linking)
VI  - 162
IP  - 2-3
DP  - 2009 Mar 15
TI  - The use of ultra high-performance liquid chromatography for studying hydrolysis 
      kinetics of CL-20 and related energetic compounds.
PG  - 1034-40
LID - 10.1016/j.jhazmat.2008.05.157 [doi]
AB  - Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with 
      sub-2-mum stationary-phase particles and allows operation with pressures of up to 
      15,000 psi to yield increased resolution, speed, and sensitivity versus 
      conventional HPLC. This promising new technology was used for the analysis of 
      energetic compounds (RDX, HMX and CL-20) and a selective method was developed on 
      an Acquity UPLC. A fast UHPLC method was applied to determine alkaline hydrolysis 
      reaction kinetics of major energetic compounds. Activation energies of alkaline 
      hydrolysis reaction for CL-20, RDX and HMX were comparable to those in 
      literature, however they were determined in a shorter amount of time due to the 
      speed of analysis of the chromatographic method. The use of liophilic salts 
      (KPF(6)) as mobile-phase additives for the enhancement of separation selectivity 
      of energetic compounds was demonstrated.
FAU - Makarov, Alexey
AU  - Makarov A
AD  - Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936, 
      United States. alexey.makarov@novartis.com
FAU - Lobrutto, Rosario
AU  - Lobrutto R
FAU - Christodoulatos, Christos
AU  - Christodoulatos C
FAU - Jerkovich, Anton
AU  - Jerkovich A
LA  - eng
PT  - Journal Article
DEP - 20080611
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane)
RN  - 0 (Aza Compounds)
RN  - 0 (Azocines)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Triazines)
RN  - LLW94W5BSJ (octogen)
RN  - W91SSV5831 (cyclonite)
SB  - IM
MH  - Aza Compounds/*chemistry
MH  - Azocines/*chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Heterocyclic Compounds/*chemistry
MH  - Hydrolysis
MH  - Kinetics
MH  - Sensitivity and Specificity
MH  - Triazines/*chemistry
EDAT- 2008/07/23 09:00
MHDA- 2009/04/08 09:00
CRDT- 2008/07/23 09:00
PHST- 2008/03/04 00:00 [received]
PHST- 2008/05/27 00:00 [revised]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/07/23 09:00 [pubmed]
PHST- 2009/04/08 09:00 [medline]
PHST- 2008/07/23 09:00 [entrez]
AID - S0304-3894(08)00832-7 [pii]
AID - 10.1016/j.jhazmat.2008.05.157 [doi]
PST - ppublish
SO  - J Hazard Mater. 2009 Mar 15;162(2-3):1034-40. doi: 10.1016/j.jhazmat.2008.05.157. 
      Epub 2008 Jun 11.