PMID- 18646719
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20080723
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 88
IP  - 9
DP  - 2008 Mar 4
TI  - [Expression of human leukocyte antigen-DR in idiopathic pulmonary fibrosis].
PG  - 622-4
AB  - OBJECTIVE: To study the expression of human leukocyte antigen (HLA)-DR in the 
      lungs of the patients with idiopathic pulmonary fibrosis (IPF), and to explore 
      the possible autoimmunity mechanisms of lung fibrosis. METHODS: Methods 
      Immunohistochemistry (SP method) was used to detect the expression of HLA-DR in 
      the lung specimens from 10 IPF patients and in 5 specimens of normal lung tissue 
      immediately adjacent to lung carcinomas as controls. RESULTS: HLA-DR antigens 
      were expressed in the hyperplastic bronchi-alveolar epithelial cells in IPF, but 
      not in the epithelial cells of the normal control lung tissues. The accumulated 
      positive scores of HLA-DR of the IPF group was 27, significantly higher than that 
      of the control group (2, Z = - 3.002, P = 0.001). CONCLUSIONS: Inappropriate 
      HLA-DR expression is present in the bronchi -alveolar epithelium in IPF. Immune 
      dysfunction may play an important role in the development of IPF.
FAU - Ni, Lian-fang
AU  - Ni LF
AD  - Department of Geriatric Medicine, Peking University First Hospital, Beijing 
      100034, China.
FAU - Na, Jia
AU  - Na J
FAU - Deng, Rui
AU  - Deng R
FAU - Wu, Rui
AU  - Wu R
FAU - Liu, Xin-min
AU  - Liu XM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Epithelium/metabolism/pathology
MH  - Female
MH  - HLA-DR Antigens/*biosynthesis/immunology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung/*metabolism/pathology
MH  - Lung Neoplasms/immunology/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Fibrosis/immunology/*metabolism/pathology
EDAT- 2008/07/24 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/07/24 09:00
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/07/24 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2008 Mar 4;88(9):622-4.