PMID- 18647362 OWN - NLM STAT- MEDLINE DCOM- 20090518 LR - 20081002 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 72 IP - 4 DP - 2008 Oct TI - Identification of two novel HLA alleles, HLA-A*02010103 and HLA-B*4455, and characterization of the complete genomic sequence of HLA-A*290201. PG - 397-400 LID - 10.1111/j.1399-0039.2008.01100.x [doi] AB - We describe two novel human leukocyte antigen (HLA) alleles, HLA-A*02010103 and HLA-B*4455, that were discovered in two unrelated Caucasian individuals. In addition, we report the full-length genomic sequence of HLA-A*290201. Compared with HLA-A*02010101, HLA-A*02010103 has three nucleotide (nt) changes within intron 1, which is altered to a sequence typical of the HLA-A*23/A*24 allele group. In HLA-B*4455, an nt exchange occurred in codon 9 of HLA-B*44020101, resulting in a change of the amino acid coding from tyrosine to histidine. We sequenced HLA-A*290201 from nt -108 to nt 2922, encompassing all exons and introns as well as parts of the 5' and 3' untranslated regions. Previously, the full-length genomic sequence was known only for HLA-A*29010101, which is found at a lower frequency in Caucasians than HLA-A*290201. FAU - Heinold, A AU - Heinold A AD - Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany. FAU - Schaller-Suefling, E AU - Schaller-Suefling E FAU - Opelz, G AU - Opelz G FAU - Scherer, S AU - Scherer S FAU - Tran, T H AU - Tran TH LA - eng PT - Journal Article DEP - 20080717 PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) SB - IM MH - *Alleles MH - Base Sequence MH - Exons/genetics MH - HLA-A Antigens/*genetics MH - HLA-B Antigens/*genetics MH - Humans MH - Introns/genetics MH - Molecular Sequence Data MH - Sequence Alignment EDAT- 2008/07/24 09:00 MHDA- 2009/05/19 09:00 CRDT- 2008/07/24 09:00 PHST- 2008/07/24 09:00 [pubmed] PHST- 2009/05/19 09:00 [medline] PHST- 2008/07/24 09:00 [entrez] AID - TAN1100 [pii] AID - 10.1111/j.1399-0039.2008.01100.x [doi] PST - ppublish SO - Tissue Antigens. 2008 Oct;72(4):397-400. doi: 10.1111/j.1399-0039.2008.01100.x. Epub 2008 Jul 17.