PMID- 18647613
OWN - NLM
STAT- MEDLINE
DCOM- 20090415
LR  - 20220316
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 56 Suppl 1
IP  - Suppl 1
DP  - 2009
TI  - Neurotrophic factors and structural plasticity in addiction.
PG  - 73-82
LID - 10.1016/j.neuropharm.2008.06.059 [doi]
AB  - Drugs of abuse produce widespread effects on the structure and function of 
      neurons throughout the brain's reward circuitry, and these changes are believed 
      to underlie the long-lasting behavioral phenotypes that characterize addiction. 
      Although the intracellular mechanisms regulating the structural plasticity of 
      neurons are not fully understood, accumulating evidence suggests an essential 
      role for neurotrophic factor signaling in the neuronal remodeling which occurs 
      after chronic drug administration. Brain-derived neurotrophic factor (BDNF), a 
      growth factor enriched in brain and highly regulated by several drugs of abuse, 
      regulates the phosphatidylinositol 3'-kinase (PI3K), mitogen-activated protein 
      kinase (MAPK), phospholipase Cgamma (PLCgamma), and nuclear factor kappa B 
      (NFkappaB) signaling pathways, which influence a range of cellular functions 
      including neuronal survival, growth, differentiation, and structure. This review 
      discusses recent advances in our understanding of how BDNF and its signaling 
      pathways regulate structural and behavioral plasticity in the context of drug 
      addiction.
FAU - Russo, Scott J
AU  - Russo SJ
AD  - Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave 
      Levy Place, New York, NY 10029, USA.
FAU - Mazei-Robison, Michelle S
AU  - Mazei-Robison MS
FAU - Ables, Jessica L
AU  - Ables JL
FAU - Nestler, Eric J
AU  - Nestler EJ
LA  - eng
GR  - R01 DA014133/DA/NIDA NIH HHS/United States
GR  - R01 DA014133-08/DA/NIDA NIH HHS/United States
GR  - R01 DA014133-09/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20080704
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/physiology
MH  - Nerve Growth Factors/*metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - Signal Transduction/*physiology
MH  - *Substance-Related Disorders/metabolism/pathology/physiopathology
PMC - PMC2635335
MID - NIHMS86817
EDAT- 2008/07/24 09:00
MHDA- 2009/04/16 09:00
PMCR- 2010/01/01
CRDT- 2008/07/24 09:00
PHST- 2008/04/24 00:00 [received]
PHST- 2008/06/10 00:00 [revised]
PHST- 2008/06/14 00:00 [accepted]
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2009/04/16 09:00 [medline]
PHST- 2008/07/24 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - S0028-3908(08)00214-1 [pii]
AID - 10.1016/j.neuropharm.2008.06.059 [doi]
PST - ppublish
SO  - Neuropharmacology. 2009;56 Suppl 1(Suppl 1):73-82. doi: 
      10.1016/j.neuropharm.2008.06.059. Epub 2008 Jul 4.