PMID- 18647952
OWN - NLM
STAT- MEDLINE
DCOM- 20081231
LR  - 20211020
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 57
IP  - 11
DP  - 2008 Nov
TI  - Association of organochlorine pesticides with peripheral neuropathy in patients 
      with diabetes or impaired fasting glucose.
PG  - 3108-11
LID - 10.2337/db08-0668 [doi]
AB  - OBJECTIVE: Recent epidemiological studies have shown that background exposure to 
      persistent organic pollutants (POPs)--xenobiotics accumulated in adipose 
      tissue--is strongly associated with type 2 diabetes. Hyperglycemia is the cause 
      of long-term complications of diabetes as well as diabetes itself, and POPs are 
      well-known neurotoxicants. This study was performed to explore whether POPs are 
      associated with peripheral neuropathy, a common long-term complication of 
      diabetes, in people with glucose abnormalities. RESEARCH DESIGN AND METHODS: We 
      studied cross-sectional associations of peripheral neuropathy with 25 POPs, each 
      of which were detectable in at least 60% of study subjects, in 246 subjects aged 
      >or=40 years with diabetes or impaired fasting glucose (IFG) using National 
      Health and Nutrition Examination Survey 1999-2002 datasets. RESULTS: Among five 
      subclasses of POPs, organochlorine pesticides showed a strong dose-response 
      relation with prevalence of peripheral neuropathy; adjusted ORs were 1.0, 3.6, 
      and 7.3 (P for trend <0.01), respectively, across three categories of serum 
      concentrations of organochlorine pesticides. Furthermore, when we restricted the 
      analyses to 187 participants with A1C <7%, the adjusted ORs were still 1.0, 3.9, 
      and 6.7 (P for trend <0.01). Organochlorine pesticides were also strongly 
      associated with the prevalence of A1C >or=7%; adjusted ORs were 1.0, 2.5, and 5.0 
      (P for trend <0.01). Specific POPs belonging to organochlorine pesticides showed 
      similar positive associations. CONCLUSIONS: This study suggests that background 
      exposure to organochlorine pesticides may be associated with higher risk of 
      peripheral neuropathic complications among those with glucose abnormalities, even 
      beyond the influence of diabetes itself.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine and Health Promotion Research Center, School of 
      Medicine, Kyungpook National University, Daegu, Korea. lee_dh@knu.ac.kr
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
FAU - Steffes, Michael
AU  - Steffes M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080722
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/chemically induced/epidemiology/*physiopathology
MH  - Diabetes Mellitus/blood/*physiopathology
MH  - Environmental Pollutants/poisoning
MH  - Female
MH  - Glucose Intolerance/blood/physiopathology
MH  - Humans
MH  - Hydrocarbons, Chlorinated/poisoning
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Peripheral Nervous System Diseases/chemically 
      induced/epidemiology/*physiopathology
MH  - Pesticides/*poisoning
PMC - PMC2570408
EDAT- 2008/07/24 09:00
MHDA- 2009/01/01 09:00
PMCR- 2009/11/01
CRDT- 2008/07/24 09:00
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2009/01/01 09:00 [medline]
PHST- 2008/07/24 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - db08-0668 [pii]
AID - 57113108 [pii]
AID - 10.2337/db08-0668 [doi]
PST - ppublish
SO  - Diabetes. 2008 Nov;57(11):3108-11. doi: 10.2337/db08-0668. Epub 2008 Jul 22.