PMID- 18648602
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100415
LR  - 20211020
IS  - 1559-3258 (Electronic)
IS  - 1559-3258 (Linking)
VI  - 5
IP  - 2
DP  - 2006 Aug 19
TI  - Role of hormesis in life extension by caloric restriction.
PG  - 163-73
LID - 10.2203/dose-response.06-005.Masoro [doi]
AB  - Caloric restriction (CR) markedly extends the life of rats, mice and several 
      other species, and it also modulates age-associated physiological deterioration 
      and delays the occurrence and/or slows progression of age-associated diseases. 
      The level of CR that retards the aging processes is a low-intensity stressor, 
      which enhances the ability of rats and mice of all ages to cope with intense 
      stressors. CR thus exhibits a hormetic action in these species, and therefore it 
      is hypothesized that hormesis plays a role in the life-extending and anti-aging 
      actions of CR. Both the findings in support of this hypothesis and those opposing 
      it are critically considered. However, it is likely that hormesis is not the only 
      process contributing to CR-induced life extension. It is proposed that two 
      general processes are involved in CR-induced life extension. One is the reduced 
      endogenous generation of damaging agents, such as reactive oxygen species. The 
      second is hormesis, which enhances processes that protect against the action of 
      damaging agents and also promotes processes that repair the damage once it 
      occurs.
FAU - Masoro, Edward J
AU  - Masoro EJ
AD  - Barshop Institute for Longevity and Aging Studies, University of Texas Health 
      Science Center, San Antonio, TX, USA. masoro@aol.com
LA  - eng
PT  - Journal Article
DEP - 20060819
PL  - United States
TA  - Dose Response
JT  - Dose-response : a publication of International Hormesis Society
JID - 101308899
PMC - PMC2477693
OTO - NOTNLM
OT  - Aging
OT  - Damage Protection
OT  - Damage Repair
OT  - Low-Intensity Stressor
EDAT- 2008/07/24 09:00
MHDA- 2008/07/24 09:01
PMCR- 2006/08/19
CRDT- 2008/07/24 09:00
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2008/07/24 09:01 [medline]
PHST- 2008/07/24 09:00 [entrez]
PHST- 2006/08/19 00:00 [pmc-release]
AID - hormes-05-163 [pii]
AID - 10.2203/dose-response.06-005.Masoro [doi]
PST - epublish
SO  - Dose Response. 2006 Aug 19;5(2):163-73. doi: 10.2203/dose-response.06-005.Masoro.