PMID- 18648836
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 266
IP  - 3
DP  - 2009 Mar
TI  - Association of laryngopharyngeal manifestations and gastroesophageal reflux.
PG  - 403-9
LID - 10.1007/s00405-008-0761-2 [doi]
AB  - The aim of this study was to investigate the prevalence of gastroesophageal 
      reflux disease (GERD) in patients with laryngopharyngeal symptoms, the 
      relationship between laryngopharyngeal reflux (LPR) and Helicobacter Pylori 
      infection and treatment response to proton pump inhibitors. Forty-five patients 
      with suspected gastroesophageal reflux diseases related symptoms (sore throat, 
      throat burning, throat clearing, globus sensation, cough, halitozis, dysphonia, 
      dysphagia, postnasal dripping, vocal fatigue, and sputum) were included in this 
      study. For pre-therapeutic and post-therapeutic comparison, symptoms and 
      laryngological findings were graded on a 4-point scale. The patients underwent 
      upper gastrointestinal system endoscopy. During endoscopy, antral biopsies from 
      the stomach were obtained to detect H. Pylori. Antireflux medication with proton 
      pump inhibitors (PPI) and H. Pylori eradication therapy if present were 
      prescribed to the patients. The improvement in symptoms and laryngological 
      findings were evaluated after treatment. By means of esophagogastroduodenoscopy 
      (EGD), reflux was detected in only 11% of patients. But there can be reflux 
      patients other than the detected ones. Although, H. Pylori was present in 62% of 
      patients, no correlation was found between H. Pylori positivity and symptoms. All 
      patients responded well to antireflux treatment and H. Pylori eradication 
      therapy. Laryngopharyngeal symptoms and findings can be predictors of 
      gastroesophageal diseases when response to reflux treatment is taken into 
      account.
FAU - Toros, Sema Zer
AU  - Toros SZ
AD  - Deparment of Otorhinolaryngology/Head and Neck Surgery, Haydarpasa Numune 
      Educational and Research Hospital, M Saadettin Sokak, Saadet Apartmani, Istanbul, 
      Ortakoy/Besiktas, Turkey. semazertoros@yahoo.com
FAU - Toros, Ahmet Burak
AU  - Toros AB
FAU - Yuksel, Ozlem Doganer
AU  - Yuksel OD
FAU - Ozel, Leyla
AU  - Ozel L
FAU - Akkaynak, Cinar
AU  - Akkaynak C
FAU - Naiboglu, Baris
AU  - Naiboglu B
LA  - eng
PT  - Journal Article
DEP - 20080722
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Endoscopy, Digestive System/methods
MH  - Esophagitis/*diagnosis
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/*epidemiology/*physiopathology
MH  - *Helicobacter Infections/drug therapy/epidemiology/microbiology
MH  - Helicobacter pylori/*isolation & purification
MH  - Humans
MH  - Lansoprazole
MH  - Larynx/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pharynx/*physiopathology
MH  - Prevalence
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2008/07/24 09:00
MHDA- 2009/07/28 09:00
CRDT- 2008/07/24 09:00
PHST- 2007/10/23 00:00 [received]
PHST- 2008/07/01 00:00 [accepted]
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
PHST- 2008/07/24 09:00 [entrez]
AID - 10.1007/s00405-008-0761-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2009 Mar;266(3):403-9. doi: 10.1007/s00405-008-0761-2. 
      Epub 2008 Jul 22.