PMID- 18649311
OWN - NLM
STAT- MEDLINE
DCOM- 20080923
LR  - 20080729
IS  - 1612-1880 (Electronic)
IS  - 1612-1872 (Linking)
VI  - 5
IP  - 7
DP  - 2008 Jul
TI  - Synthetic antimicrobial peptides as agricultural pesticides for plant-disease 
      control.
PG  - 1225-37
LID - 10.1002/cbdv.200890111 [doi]
AB  - There is a need of antimicrobial compounds in agriculture for plant-disease 
      control, with low toxicity and reduced negative environmental impact. 
      Antimicrobial peptides are produced by living organisms and offer strong 
      possibilities in agriculture because new compounds can be developed based on 
      natural structures with improved properties of activity, specificity, 
      biodegradability, and toxicity. Design of new molecules has been achieved using 
      combinatorial-chemistry procedures coupled to high-throughput screening systems 
      and data processing with design-of-experiments (DOE) methodology to obtain QSAR 
      equation models and optimized compounds. Upon selection of best candidates with 
      low cytotoxicity and moderate stability to protease digestion, anti-infective 
      activity has been evaluated in plant-pathogen model systems. Suitable compounds 
      have been submitted to acute toxicity testing in higher organisms and exhibited a 
      low toxicity profile in a mouse model. Large-scale production can be achieved by 
      solution organic or chemoenzymatic procedures in the case of very small peptides, 
      but, in many cases, production can be performed by biotechnological methods using 
      genetically modified microorganisms (fermentation) or transgenic crops (plant 
      biofactories).
FAU - Montesinos, Emilio
AU  - Montesinos E
AD  - Institute of Food and Agricultural Technology-CIDSAV-XaRTA, University of Girona, 
      Campus Montilivi, E-18071 Girona. emonte@intea.udg.edu
FAU - Bardaji, Eduard
AU  - Bardaji E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Chem Biodivers
JT  - Chemistry & biodiversity
JID - 101197449
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Pesticides)
SB  - IM
MH  - Animals
MH  - Antimicrobial Cationic Peptides/*chemical synthesis/pharmacology
MH  - Combinatorial Chemistry Techniques
MH  - Microbial Sensitivity Tests
MH  - Peptide Fragments/chemical synthesis/pharmacology
MH  - Peptides, Cyclic/chemical synthesis/pharmacology
MH  - Pesticides/*chemical synthesis/pharmacology
MH  - *Plant Diseases
RF  - 91
EDAT- 2008/07/24 09:00
MHDA- 2008/09/24 09:00
CRDT- 2008/07/24 09:00
PHST- 2008/07/24 09:00 [pubmed]
PHST- 2008/09/24 09:00 [medline]
PHST- 2008/07/24 09:00 [entrez]
AID - 10.1002/cbdv.200890111 [doi]
PST - ppublish
SO  - Chem Biodivers. 2008 Jul;5(7):1225-37. doi: 10.1002/cbdv.200890111.