PMID- 18651322
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20221207
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 68
IP  - 8
DP  - 2008
TI  - Effect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish 
      patients with premature coronary artery disease.
PG  - 801-5
LID - 10.1080/00365510802287257 [doi]
AB  - OBJECTIVES: It has been suggested that monocyte chemoattractant protein-1 (MCP-1) 
      is important in the initiation of atherosclerosis and crucial in monocyte 
      recruitment into the subendothelial lesions. Recent studies have demonstrated 
      that MCP-1 -2518 A>G polymorphism is associated with susceptibility to coronary 
      artery disease (CAD). Since there are conflicting reports on the possible 
      association of MCP-1 -2518 A>G polymorphism with CAD, we investigated the role of 
      this polymorphism in Turkish patients with premature CAD. MATERIAL AND METHODS: 
      Genomic DNA was collected from 171 premature CAD patients and 151 healthy 
      individuals. MCP-1 -2518 A>G polymorphism was genotyped using the PCR-RFLP 
      method. RESULTS: There were no differences between genotype distribution and 
      allele frequencies in the premature CAD and control groups (AA: 49.7 %; AG: 40.3 
      %; GG: 10.0 % in premature CAD groups and AA: 53.7 %; AG: 34.4 %; GG: 11.9 % in 
      controls; p = 0.53). The prevalence of the G allele was 0.302 in patients and 
      0.291 in controls. CONCLUSIONS: Our data demonstrate that MCP-1 -2518 A>G 
      polymorphism is not associated with premature CAD in Turkish patients. Further 
      studies are needed to elucidate the role of this polymorphism in the pathogenesis 
      of CAD in various populations.
FAU - Cam, Sirri F
AU  - Cam SF
AD  - Department of Medical Biology and Genetics, Faculty of Medicine, Celal Bayar 
      University, Manisa, Turkey. sirri.cam@bayar.edu.tr
FAU - Sekuri, Cevad
AU  - Sekuri C
FAU - Sagcan, Abdi
AU  - Sagcan A
FAU - Ercan, Ertugrul
AU  - Ercan E
FAU - Tengiz, Istemihan
AU  - Tengiz I
FAU - Alioglu, Emin
AU  - Alioglu E
FAU - Berdeli, Afig
AU  - Berdeli A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/*genetics
MH  - Demography
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Turkey
EDAT- 2008/07/25 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/07/25 09:00
PHST- 2008/07/25 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/07/25 09:00 [entrez]
AID - 795276545 [pii]
AID - 10.1080/00365510802287257 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2008;68(8):801-5. doi: 10.1080/00365510802287257.